Ivermectin with nitazoxanide eliminate cryptosporidium intestinal infection in immunocompromized mice and upregulate cytokeratin 20 expression, enhancing intestinal cellular healing
Joint Authors
Nahnush, Riham K.
al-Mallawani, Marwah A.
al-Askari, Halah M.
Source
Journal of the Egyptian Society of Parasitology
Issue
Vol. 52, Issue 1 (30 Apr. 2022), pp.9-14, 6 p.
Publisher
The Egyptian Society of Parasitology
Publication Date
2022-04-30
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Topics
Abstract EN
Cryptosporidiosis is an extensively spread protozoan parasite, but its immense cellular threat is limited to those suffering from immune suppression which may encounter fatal complications.
this study assessed the nitazoxanide effect alone or combined with ivermectin on eradicating cryptosporidiosis and enhancing cellular healing in immunocompromized infected mice using cytokeratin 20 as an intestinal intermediate filament protein marker to reflect intestinal cellular integrity.
oocyst count in mice treated by nitazoxanide monotherapy was significantly higher (37 × 103 ± 7.3) than those treated with combined therapy (5×103 ± 4.1).
reduction rate was higher in mice treated with both therapy (95.7%) than mice treated with monotherapy (68.9%).
considerably high cytokeratin expression was recorded in mice treated with combined therapy (34.64±6.65), possibly indicated the intestinal mucosa recovery, while a relatively lower expression was in mice treated with nitazoxanide monotherapy (21.28 ± 9.41) (p < 0.05).
American Psychological Association (APA)
al-Askari, Halah M.& Nahnush, Riham K.& al-Mallawani, Marwah A.. 2022. Ivermectin with nitazoxanide eliminate cryptosporidium intestinal infection in immunocompromized mice and upregulate cytokeratin 20 expression, enhancing intestinal cellular healing. Journal of the Egyptian Society of Parasitology،Vol. 52, no. 1, pp.9-14.
https://search.emarefa.net/detail/BIM-1341053
Modern Language Association (MLA)
al-Askari, Halah M.…[et al.]. Ivermectin with nitazoxanide eliminate cryptosporidium intestinal infection in immunocompromized mice and upregulate cytokeratin 20 expression, enhancing intestinal cellular healing. Journal of the Egyptian Society of Parasitology Vol. 52, no. 1 (Apr. 2022), pp.9-14.
https://search.emarefa.net/detail/BIM-1341053
American Medical Association (AMA)
al-Askari, Halah M.& Nahnush, Riham K.& al-Mallawani, Marwah A.. Ivermectin with nitazoxanide eliminate cryptosporidium intestinal infection in immunocompromized mice and upregulate cytokeratin 20 expression, enhancing intestinal cellular healing. Journal of the Egyptian Society of Parasitology. 2022. Vol. 52, no. 1, pp.9-14.
https://search.emarefa.net/detail/BIM-1341053
Data Type
Journal Articles
Language
English
Notes
Includes appendices : p. 13-14
Record ID
BIM-1341053