Multiple sclerosis and vitamin D : is there a link in the multifactorial model?

Abstract EN

MS is a rare neurodegenerative disease with an immunopathological background.

although, it has a rather low global prevalence, it can be considered among one of the most common youth disabling disorders that are not related to trauma.

it is also classified as a complex disease with many susceptibility genes incriminated in its etiology and prognosis.

in addition, several well identified and extensively studied environmental factors are implicated as vitamin D metabolism & ultraviolet b (UVB) exposure, Epstein BARR virus (EBV) infection, smoking and morbid obesity.

the infamous relationship between vitamin D and MS has been an area of extensive research in many aspects ; pathophysiology, disease course, prognosis and even response to treatment.