Histopathologic study on the toxic effect of aluminium chloride on the heart liver and kidneys of rabbits
Joint Authors
Khafajah, Asma F.
Tuhami, Husam G.
Sad, Hibah Allah M.
Hasib, Mustafa M.
Awdah, Samah S.
Source
Alexandria Journal of Veterinary Sciences
Issue
Vol. 56, Issue 1 (31 Jan. 2018), pp.102-109, 8 p.
Publisher
Alexandria University Faculty of Veterinary Medicine
Publication Date
2018-01-31
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The present study was designed to investigate the adverse effects of aluminum chloride hexahydrate on the heart, liver and kidneys of rabbits.
twenty-four apparently healthy male and female rabbits were randomly assigned to four groups.
the two control groups male (n= 6) and female (n= 6) received subcutaneous injections of physiological saline.
the other two al-treated groups of male (n= 6) and female (n= 6) were given 2.5mg/kg b.w.
s/c five times per week for 3 months.
at the 6th weeks and the 12th weeks, three rabbits from each group were necropsied and tissues specimens from heart, liver and kidneys were collected and processed for the following histopathologic examination.
the heart of both sexes of intoxicated rabbits showed congestion of blood vessels, interfibrillar edema, hemorrhage as well as zenker's degeneration and necrosis of myocardium.
the liver showed periportal edema, mild fibroplasia, infiltration of inflammatory cells, adenomatous and papillary hyperplasia of bile ductules.
the encountered lesions of the kidneys were in the form of vacuolations and necrosis of renal tubular epithelium, with intratubular necrotic cellular debris and hyaline casts.
an additional lesion of severe interstitial nephritis was also seen in some areas.
it was concluded that the adverse toxic effects of aluminum chloride were time-dependent manner on heart, kidneys and liver of of both sexes of rabbits.
American Psychological Association (APA)
Sad, Hibah Allah M.& Hasib, Mustafa M.& Awdah, Samah S.& Tuhami, Husam G.& Khafajah, Asma F.. 2018. Histopathologic study on the toxic effect of aluminium chloride on the heart liver and kidneys of rabbits. Alexandria Journal of Veterinary Sciences،Vol. 56, no. 1, pp.102-109.
https://search.emarefa.net/detail/BIM-1342993
Modern Language Association (MLA)
Sad, Hibah Allah M.…[et al.]. Histopathologic study on the toxic effect of aluminium chloride on the heart liver and kidneys of rabbits. Alexandria Journal of Veterinary Sciences Vol. 56, no. 1 (Jan. 2018), pp.102-109.
https://search.emarefa.net/detail/BIM-1342993
American Medical Association (AMA)
Sad, Hibah Allah M.& Hasib, Mustafa M.& Awdah, Samah S.& Tuhami, Husam G.& Khafajah, Asma F.. Histopathologic study on the toxic effect of aluminium chloride on the heart liver and kidneys of rabbits. Alexandria Journal of Veterinary Sciences. 2018. Vol. 56, no. 1, pp.102-109.
https://search.emarefa.net/detail/BIM-1342993
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 108-109
Record ID
BIM-1342993