Association between serum vitamin D level and lipid profile in a Jordanian adult cohort

Abstract EN

-Aim: The main aim of our study was to investigate the association between vitamin D levels and lipid profiles in a Jordanian adult cohort.

Methods: This retrospective study was conducted during the period from January 2017 to February 2018 on 762 patients who attended the internal medicine clinics at King Hussein Medical Centre in Amman.

Blood samples were analysed at the Department of Chemistry of the Princess Iman Centre for Research and Laboratory Sciences using Cobas e411 analyser to determine serum 25hydroxyvitamin D3 (25[OH] D3) levels, and Cobas 501 for lipid profile analysis (triglycerides, total cholesterol, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol levels).

Data were analysed using the statistical software SPSS version 20.0.

The observed differences in values were analysed for statistical significance and a p-value of <0.05 was considered significant.

Results: Of the 762 subjects, 300 (39.37%) were vitamin D deficient, 416 (54.59%) were insufficient and 46 (6.04%) had sufficient levels.

We found a positive significant correlation between 25(OH)D3 and triglycerides (β coefficient = 0.258, p = 0.000), total cholesterol (β coefficient = 0.194, p = 0.000), low-density lipoprotein cholesterol (β coefficient = 0.279, p = 0.000) and high-density lipoprotein cholesterol (β coefficient = 0.149, p= 0.000).

Conclusion: Our present study showed a direct positive association between vitamin D level and triglycerides, cholesterol, low-density lipoprotein and high-density lipoprotein