Role of transient receptor potential vanilloid 4 channel in skin physiology and pathology
Other Title(s)
دور قناة مستقبلة فانلويد 4 ذات الجهد المؤقت في وظائف الجلد و أمراضه
Joint Authors
Bu Daghah, Ammar
al-Yazidi, Malik
al-Lawati, Intisar
Source
Sultan Qaboos University Medical Journal
Issue
Vol. 20, Issue 2 (31 May. 2020), pp.138-146, 9 p.
Publisher
Sultan Qaboos University College of Medicine and Health Sciences
Publication Date
2020-05-31
Country of Publication
Oman
No. of Pages
9
Main Subjects
Abstract EN
Transient receptor potential vanilloid 4 (TRPV4) channel responds to temperature, as well as various mechanical and chemical stimuli.
This non-selective cation channel is expressed in several organs, including the blood vessels, kidneys, oesophagus and skin.
In the skin, TRPV4 channel is present in various cell types such as keratinocytes, melanocytes and sensory neurons, as well as immune and inflammatory cells, and engages in several physiological actions, from skin homeostasis to sensation.
In addition, there is substantial evidence implicating dysfunctional TRPV4 channel—in the form of either deficient or excessive channel activity—in pathological cutaneous conditions such as skin barrier compromise, pruritus, pain, skin inflammation and carcinogenesis.
These varied functions, combined with the fact that TRPV4 channel owns pharmacologically-accessible sites, make this channel an attractive therapeutic target for skin disorders.
In this review, we summarize the different physiological and pathophysiological effects of TRPV4 in the skin.
American Psychological Association (APA)
Bu Daghah, Ammar& al-Yazidi, Malik& al-Lawati, Intisar. 2020. Role of transient receptor potential vanilloid 4 channel in skin physiology and pathology. Sultan Qaboos University Medical Journal،Vol. 20, no. 2, pp.138-146.
https://search.emarefa.net/detail/BIM-1346090
Modern Language Association (MLA)
Bu Daghah, Ammar…[et al.]. Role of transient receptor potential vanilloid 4 channel in skin physiology and pathology. Sultan Qaboos University Medical Journal Vol. 20, no. 2 (May. 2020), pp.138-146.
https://search.emarefa.net/detail/BIM-1346090
American Medical Association (AMA)
Bu Daghah, Ammar& al-Yazidi, Malik& al-Lawati, Intisar. Role of transient receptor potential vanilloid 4 channel in skin physiology and pathology. Sultan Qaboos University Medical Journal. 2020. Vol. 20, no. 2, pp.138-146.
https://search.emarefa.net/detail/BIM-1346090
Data Type
Journal Articles
Language
English
Record ID
BIM-1346090