Liver function tests pre-and post-cholecystectomy in gall bladder stone patients

Abstract EN

Objective : To determine the changes in some liver function tests in gall stone patients before, after one week and after one month of cholecystectomy. Methods: Sixty patients (19 males and 41 females), ages ranged from 22-79 years, were included in this study.

All of them underwent cholecystectomy in either of two hospitals (Al-Zahrawae General hospital and Ninevah Private Hospital) during a period of six months from 1st October 2004 to 31st March 2005.

The following tests were performed: total serum bilirubin, direct serum bilirubin, alanine aminotransferase activity, aspartate aminotransferase activity, alkaline phosphatase activity, total serum protein and serum albumin. Results: The results of the data analyzed are presented according to the intervals at which the samples were obtained from the patients as follows: Day of cholecystectomy, after one week of cholecystectomy, and after one month of cholecystectomy.

There was a significant reduction in total serum bilirubin, direct serum bilirubin, alanine transaminase, aspartate transaminase activities after one month of cholecystectomy when compared to that before and after one week of operation.

Meanwhile, a significant elevation in alkaline phosphatase activity after cholecystectomy in both intervals.

The maximum elevation was after one week, and then it decreases significantly after one month of cholecystectomy when compared to that after one week of operation. Conclusions: Gall stone is an important cause of significant pathological changes in some liver profile parameters, these parameters will return toward normal after cholecystectomy.

This normalization will be increased with the time.