Fructose-induced insulin resistance : prospective biochemical mechanisms
Other Title(s)
مقاومة الأنسولين المحفزة بالفركتوز : الآليات الكيميائية الحيوية المحتملة في الأردن
Joint Authors
al-Qinnah, Nidal Adil
al-Tamimi, Lina Nasir
Ahmad, Musa Numan
Source
Jordan Journal of Agricultural Sciences
Issue
Vol. 17, Issue 4 (31 Dec. 2021), pp.433-445, 13 p.
Publisher
University of Jordan Deanship of Academic Research (DAR)
Publication Date
2021-12-31
Country of Publication
Jordan
No. of Pages
13
Main Subjects
Abstract EN
Increased intake of dietary fructose is markedly associated with multiple negative health outcomes and burdens.
Insulin resistance (IR) and type 2 diabetes mellitus (T2DM) are the most common complications that present with conjugated cellular-biochemical abnormalities.
This article explains the involvement of increased dietary fructose intake in the occurrence of IR and T2DM and addresses basic metabolic mechanisms.
PubMed, Medline, Science Direct, ADI, and WHO databases were searched through June 2021.
Current research predicts that over 350 million people may have diabetes by 2030.
IR acts as an influencer promoter of T2DM development.
IR can occur as a result of high fructose intake.
Fructose metabolism results in de novo lipogenesis, while its decreasing effect of peroxisome proliferator-activated receptor (PPAR) activity elevates the levels of inflammatory cytokines, resulting in down-regulation of insulin receptor substrate-1 phosphorylation.
Fructose stimulates oxidative stress by activating nicotinamide adenine dinucleotide phosphate oxidase and synthesis of advanced glycation end-products.
Fructose also stimulates purine-induced uric acid synthesis and leptin resistance, which contributes to abnormal insulin action.
It is crucial to understand the mechanisms of fructose-induced IR via induction of oxidative stress, inflammation, leptin resistance, and uric acid production.
This helps prevent and control variable diseases, T2DM being the most.
American Psychological Association (APA)
al-Tamimi, Lina Nasir& Ahmad, Musa Numan& al-Qinnah, Nidal Adil. 2021. Fructose-induced insulin resistance : prospective biochemical mechanisms. Jordan Journal of Agricultural Sciences،Vol. 17, no. 4, pp.433-445.
https://search.emarefa.net/detail/BIM-1346538
Modern Language Association (MLA)
al-Tamimi, Lina Nasir…[et al.]. Fructose-induced insulin resistance : prospective biochemical mechanisms. Jordan Journal of Agricultural Sciences Vol. 17, no. 4 (2021), pp.433-445.
https://search.emarefa.net/detail/BIM-1346538
American Medical Association (AMA)
al-Tamimi, Lina Nasir& Ahmad, Musa Numan& al-Qinnah, Nidal Adil. Fructose-induced insulin resistance : prospective biochemical mechanisms. Jordan Journal of Agricultural Sciences. 2021. Vol. 17, no. 4, pp.433-445.
https://search.emarefa.net/detail/BIM-1346538
Data Type
Journal Articles
Language
English
Notes
Record ID
BIM-1346538