Parental age and the risk of autism spectrum disorder in Oman : a case-control study
Joint Authors
al-Muammari, Watfah
Jabr, Ahlam
Fombonne, Eric
Idris, Ahmad Babakr
Jalees, Saquib
Jalees, Saquib
al-Jabiri, Muna
al-Zadjali, Ala A.
Source
Sultan Qaboos University Medical Journal
Issue
Vol. 21, Issue 3 (31 Aug. 2021), pp.465-471, 7 p.
Publisher
Sultan Qaboos University College of Medicine and Health Sciences
Publication Date
2021-08-31
Country of Publication
Oman
No. of Pages
7
Main Subjects
Abstract EN
Objective: This study aimed at evaluating advanced parental age as a risk factor for Autism Spectrum Disorder (ASD) in an Omani cohort.
Methods: Case-control study of 278 ASD cases compared with 722 sex-matched controls retrieved from the electronic records of the Developmental Paediatric Clinic, Sultan Qaboos University Hospital (SQUH) between January 2015 and June 2016.
Results: ASD cases (76.6% male) were mostly diagnosed between 3-4 years of age, with more than 50% of them originating from Muscat and Batinah governorates.
Compared to controls, mothers from the case group had significantly higher educational level (post-secondary education versus high school/no formal education (odds-ratio (OR)=1.62; 95% C.I.
1.20-2.19).
In a multivariate logistic regression, the odds ratio of maternal age as a risk for ASD increased dramatically with advancing age category (using age<25 as a reference, OR was 3.39, 6.12, 7.86 and 13.13 for age categories 25-29, 30-34, 35-39, and ≥40 years, respectively).
The ORs of advancing paternal age as a risk for ASD were also statistically significant (using age<30 as referent, OR was 2.20, 2.36, and 3.12 for age categories 30-34, 35-39 and 40-44 years); however, there was a drop in the effect with paternal age ≥ 45 years (OR=1.42; 95% C.I .64-3.15).
Conclusion: Both maternal and paternal increased age were associated with a higher risk of ASD; however, the association was more pronounced and more consistent with advanced maternal age compared to paternal age.
American Psychological Association (APA)
al-Muammari, Watfah& Idris, Ahmad Babakr& al-Zadjali, Ala A.& Jalees, Saquib& Jalees, Saquib& al-Jabiri, Muna…[et al.]. 2021. Parental age and the risk of autism spectrum disorder in Oman : a case-control study. Sultan Qaboos University Medical Journal،Vol. 21, no. 3, pp.465-471.
https://search.emarefa.net/detail/BIM-1346642
Modern Language Association (MLA)
al-Muammari, Watfah…[et al.]. Parental age and the risk of autism spectrum disorder in Oman : a case-control study. Sultan Qaboos University Medical Journal Vol. 21, no. 3 (Aug. 2021), pp.465-471.
https://search.emarefa.net/detail/BIM-1346642
American Medical Association (AMA)
al-Muammari, Watfah& Idris, Ahmad Babakr& al-Zadjali, Ala A.& Jalees, Saquib& Jalees, Saquib& al-Jabiri, Muna…[et al.]. Parental age and the risk of autism spectrum disorder in Oman : a case-control study. Sultan Qaboos University Medical Journal. 2021. Vol. 21, no. 3, pp.465-471.
https://search.emarefa.net/detail/BIM-1346642
Data Type
Journal Articles
Language
English
Notes
Record ID
BIM-1346642