Impact of (Cu-Zn)‎ superoxide dismutase activity and malondyaldehyde concentration on females infertility

Abstract EN

Oxidative stress (OS) induces infertility in women through a variety of mechanisms.

ovarian follicles experiencing os can lead to direct damage to oocytes.

oocytes and spermatozoa can also experience direct damage, which can lead to impaired fertilization due to an environment of os in the peritoneal cavity.

reactive oxygen species (ROS)-antioxidant imbalance is also implicated in luteal regression and insufficient luteal hormonal support for the continuation of a pregnancy.

the current study was designed to investigate the changes of OS in primary and secondary infertility of females with different etiology.

to achieve the intended aim, a cross section study was conducted on 50 infertile females.

markers of OS, level of malonyldialdehyde (MDA) for free radicals and antioxidants (Cu – Zn) superoxide dismutase ((Cu-Zn) SOD) as scavenging enzyme was measured in blood of these females.

the results indicated a significant (p<0.03) increase of MDA concentration and insignificant (p<0.288) decreases of (Cu-Zn) SOD activities in the infertile women with those of female factor when compared with those of male factor.

the linear regression analysis demonstrated significant (r = 0.215, p<0.022) positive correlation for MDA levels with the duration of infertility.

this study favored the significant role of free radicals injury in cases of female infertility and changes of oxidative stress were observed to be dependent on the etiology and the duration of infertility of the enrolled women.