Synthesis and characterization of new (N E thyl A crylamide Mefenamate)‎

Abstract EN

In this research, a new carrier polymer was prepared through two steps, which included modification of polyacrylic acid (P1) with ethanol amine producing N-ethanol acrylic amide polymer (P2) then reacting it with mefenamic acid would give mefenamate ester polymer (P3) as a new drug carrier polymer.

ethanol amine was used as spacer between polyacrylic acid and mefenamic acid, which could have a potential use as a carrier for drug delivery system due to extended pendant drug.

the evaluation of sustained release of mefenamic acid was studied through hydrolysis of ester attachment bond by invitro drug release, using different pH values at 37℃.

the prepared prodrug polymer was characterized by FTIR and1H−NMR spectra physical properties and intrinsic viscosity were determined.

it was concluded that the spacer group acts as an extended group to be easy hydrolysised during controlled release.