Hymenialdisine is cytotoxic against cisplatin-sensitive but not against cisplatin-resistant cell lines
Joint Authors
Al-Bahlani, Shadia
Abd Allah, Nada
al-Balushi, Najwa
Hasan, Sayyid I.
Dobretsov, Sergey
al-Tamimi, Yahya
Burney, Ikram
Source
Sultan Qaboos University Medical Journal
Issue
Vol. 21, Issue 4 (30 Nov. 2021), pp.632-634, 3 p.
Publisher
Sultan Qaboos University College of Medicine and Health Sciences
Publication Date
2021-11-30
Country of Publication
Oman
No. of Pages
3
Main Subjects
Abstract EN
Objectives: New compounds are needed to overcome the resistance to commonly used cytotoxic chemotherapy for epithelial ovarian cancer.
Marine sponges are a rich source of diverse chemical compounds and hymenialdisine has been found to have antiproliferative effects.
This study aimed to investigate the cytotoxic effect of hymenialdisine in cisplatin-sensitive and cisplatin resistant ovarian cancer cell lines.
Methods: This study took place at Sultan Qaboos University, Muscat, Oman between August and November, 2019.
The anti-cancer effects of hymenialdisine or cisplatin were assessed using treating cells with different concentrations of hymenialdisine and cisplatin.
Cell viability was determined using the AlamarBlue® Assay.
Results: The half-maximal inhibitory concentration (IC50) of cisplatin was estimated at 31.4 μM for A2780S and 76.9 μM for A2780CP, whereas the IC50 of hymenialdisine was evaluated at 146.8 μM for A2780S cells.
Despite the higher concentrations of hymenialdisine (up to 300 μM), IC50 could not be determined for the A2780CP cell line.
Conclusion: When compared to cisplatin, hymenialdisine was less toxic against both A2780S and A2780CP ovarian cancer cell lines-
American Psychological Association (APA)
Abd Allah, Nada& al-Balushi, Najwa& Hasan, Sayyid I.& Al-Bahlani, Shadia& Dobretsov, Sergey& al-Tamimi, Yahya…[et al.]. 2021. Hymenialdisine is cytotoxic against cisplatin-sensitive but not against cisplatin-resistant cell lines. Sultan Qaboos University Medical Journal،Vol. 21, no. 4, pp.632-634.
https://search.emarefa.net/detail/BIM-1356637
Modern Language Association (MLA)
Abd Allah, Nada…[et al.]. Hymenialdisine is cytotoxic against cisplatin-sensitive but not against cisplatin-resistant cell lines. Sultan Qaboos University Medical Journal Vol. 21, no. 4 (Nov. 2021), pp.632-634.
https://search.emarefa.net/detail/BIM-1356637
American Medical Association (AMA)
Abd Allah, Nada& al-Balushi, Najwa& Hasan, Sayyid I.& Al-Bahlani, Shadia& Dobretsov, Sergey& al-Tamimi, Yahya…[et al.]. Hymenialdisine is cytotoxic against cisplatin-sensitive but not against cisplatin-resistant cell lines. Sultan Qaboos University Medical Journal. 2021. Vol. 21, no. 4, pp.632-634.
https://search.emarefa.net/detail/BIM-1356637
Data Type
Journal Articles
Language
English
Notes
Record ID
BIM-1356637