Antioxidant, anti-inflammatory and wound healing of biosynthetic gold nanoparticles using mangosteen (g. mangostona)
Source
Iraqi Journal of Industrial Research
Issue
Vol. 8, Issue 2 (31 Aug. 2021), pp.59-74, 16 p.
Publisher
Ministry of Industry and Minerals Corporation of Research and Industrial Development
Publication Date
2021-08-31
Country of Publication
Iraq
No. of Pages
16
Main Subjects
Topics
Abstract EN
In current research, the synthesis of gold nanoparticles was achieved via reducing of gold ions in aqueous solution with Garcinia mangostana (G.
mangostana) peel extract.
The optimum concentration of gold (Au) solution, concentration ratio of Au solution and extract, temperature, time and pH, the synthesized AuNPs (G.
mangostana-gold nanoparticles) were studied by using UV-Vis, FT-IR, AAS, AFM, SEM and Zitasizer.
The orbance peak is noticed between 535-550 nm via UV-Vis spectroscopic method.
The SEM, AFM analysis were proofed the particle as spherical in structure and their size between 15-100nm.
Therefore, mechanism of AuNPs synthesis had been suggested.
Also, the antibacterial activity was examined using different bacteria as well as free radical scavenging activity was tested using 1, 1-Diphenyl-2-picrylhydrazyl (DPPH).
The AuNPs produced through biosynthesized method indicated a much elevated antioxidant activity as compared to peel extract of G.
mangostana.
Toxicity of the NPs and extract were tested via giving orally dose 50 mg/b.
w.
to mice.
Diagnosis of the data (pathological changes) indicated that the AuNPs was non-toxic.
The G.
mangostana peel extract and AuNPs synthesized by this extract were converted to a cream and used as a wound healing cream.
As a results, the AuNPs exhibited important role in wound healing progression compared to control, which may be attributed to their anti-inflammatory, antibacterial and antioxidant activities.
Therefore, this research confirms its important use of AuNPs and can be utilized as promising agents for in the development of new In current research, the synthesis of gold nanoparticles was achieved via reducing of gold ions in aqueous solution with Garcinia mangostana (G.
mangostana) peel extract.
The optimum concentration of gold (Au) solution, concentration ratio of Au solution and extract, temperature, time and pH, the synthesized AuNPs (G.
mangostana-gold nanoparticles) were studied by using UV-Vis, FT-IR, AAS, AFM, SEM and Zitasizer.
The orbance peak is noticed between 535-550 nm via UV-Vis spectroscopic method.
The SEM, AFM analysis were proofed the particle as spherical in structure and their size between 15-100nm.
Therefore, mechanism of AuNPs synthesis had been suggested.
Also, the antibacterial activity was examined using different bacteria as well as free radical scavenging activity was tested using 1, 1-Diphenyl-2-picrylhydrazyl (DPPH).
The AuNPs produced through biosynthesized method indicated a much elevated antioxidant activity as compared to peel extract of G.
mangostana.
Toxicity of the NPs and extract were tested via giving orally dose 50 mg/b.
w.
to mice.
Diagnosis of the data (pathological changes) indicated that the AuNPs was non-toxic.
The G.
mangostana peel extract and AuNPs synthesized by this extract were converted to a cream and used as a wound healing cream.
As a results, the AuNPs exhibited important role in wound healing progression compared to control, which may be attributed to their anti-inflammatory, antibacterial and antioxidant activities.
Therefore, this research confirms its important use of AuNPs and can be utilized as promising agents for in the development of new drugs.
American Psychological Association (APA)
Muhammad, Mustafa Taha. 2021. Antioxidant, anti-inflammatory and wound healing of biosynthetic gold nanoparticles using mangosteen (g. mangostona). Iraqi Journal of Industrial Research،Vol. 8, no. 2, pp.59-74.
https://search.emarefa.net/detail/BIM-1366664
Modern Language Association (MLA)
Muhammad, Mustafa Taha. Antioxidant, anti-inflammatory and wound healing of biosynthetic gold nanoparticles using mangosteen (g. mangostona). Iraqi Journal of Industrial Research Vol. 8, no. 2 (2021), pp.59-74.
https://search.emarefa.net/detail/BIM-1366664
American Medical Association (AMA)
Muhammad, Mustafa Taha. Antioxidant, anti-inflammatory and wound healing of biosynthetic gold nanoparticles using mangosteen (g. mangostona). Iraqi Journal of Industrial Research. 2021. Vol. 8, no. 2, pp.59-74.
https://search.emarefa.net/detail/BIM-1366664
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 72-74
Record ID
BIM-1366664