Comparative study among, olive, avocado, and mango leaves in diabetic rats

Abstract EN

This study was conducted to acquaintance the effectiveness of olive , avocado and mango leaves on experimental rats suffering from diabetes mellitus.

Forty-five male albino rats weighing 190 ±10 g were used.

After the adaptation period , rats were divided randomly into two main groups; the negative control group (C-) 5 normal rats fed on a basal diet and the second group (n=40) were injected subcutaneously with Streptozotocin (STZ) at (45 mg/kg b.wt ) dissolved in 0.01 M citrate buffer (PH 4.5).Then rats were divided into eight groups (each group consisted of 5 rats group of them fed on basal diet and left as positive control group (+) ,the other groups treated with, Metformin at dose 200mg/kg b.wt , olive leaves powder 3%, Mango leaves powder 3%, Avocado leaves powder 3%, olive leaves aqueous extract 20% ,mango leaves aqueous extract 20% and Avocado leaves aqueous extract 20%.

Results showed that (STZ) injection led to a significant elevation in the relative weights of the liver, kidney and pancreas ,serum levels of glucose , triglyceride ,total cholesterol, LDL-C, liver enzymes, creatinine and urea nitrogen.

Conversely , feed intake , body weight and HDL-c were significantly reduced.

In general , it has been shown that the leaves of olive , mango and avocado as a powder or as aqueous extract have antioxidant and hypoglycemic effects ,so they alleviated the studied disorder were resulting from hyperglycemia.