Changes in serum calcium, phosphate, albumin and parathyroid hormone before and after hemodial ysis in Sudanese patients with end - stage renal failure

Abstract EN

Objective: to determine the concentrations of serum parathyroid hormone (PTH) and bone minerals and their association before and after hemodialysis. Methods: A cross sectional study was done on patients with end-stage renal disease (ESRD) on treatment with maintenance hemodialysis (HD).

Levels of serum calcium, phosphate, urea, creatinine, albumin, and intact parathormone (iPTH) were measured. Results: The total number of patients studied was 50 (40 males; 10 femals), the mean age was 40.3+26.5 years, and the average duration on hemodialysis (HD) was 53 months.

Serum PTH level was significantly lower after hemodialysis treatment; it was 945.8+995.9 pg / ml and 781.7+928.1 pg / ml before and after HD respectively, but still over the normal range.

Serum phosphate concentration was remarkably differ before and after HD (5.59+1.8 mg / ml vs 4.38+1.2 mg / ml respectively).

In contrast, the mean value of serum calcium concentration was changed significantly after HD (6.7+1.5 mg / dl) compared with the level before HD (5.6+6.7 mg / dl).

PTH correlated positively with phosphate (r-0.30, p-0.03), and negatively with calcium (r=-0.299, p-0.04) levels.

A significant decrease in serum urea and creatinine levels was reported after HD.

Serum albumin showed no significant difference before and after HD. Conclusions: PTH was remarkably decreased post dialysis in our patients with definite increased serum Ca+.

There is no significant difference between PTH and patient's age, sex and duration in HD Sudanese patients.