Histological effects of the interaction of some food additives on the kidney of pregnant rats

Abstract EN

Many studies are still the subject of food additives to know their positive and negative effects, primarily as they are widely used globally.

therefore, this study aimed to identify the histological effects of sodium nitrite and monosodium glutamate on the histological structure of the kidney in pregnant rats.

twenty-four pregnant rats were used to achieve the aim of the study.

the rats were classified into four groups, the first being the control group, the second treated with monosodium glutamate at 10 g / kg, the third injected with sodium nitrite at 115 mg / kg, and the fourth for interaction between the two substances and for the same concentrations.

the results showed the occurrence of many lesions in the kidneys of experimental groups rats.

the second group included interstitial tissue hyperplasia and necrosis of the glomeruli, infiltration of inflammatory cells, congestion of blood vessels, hydropic degeneration of some tubules, and necrosis of some of them.

the third group included congestion, hemorrhage in the pulp area, degeneration of some urinary tubules, necrosis, and deformation of the glomerulus.

however, degeneration of some tubules and necrosis were seen in the fourth group, such as glomerulus hyperplasia, reduction of bowman's space, an increase in acidity of the cytoplasm of epithelial cells tubules, hyperplasia of the fibroblasts, and the desquamation of some tubules.

the study concluded that these substances have harmful effects on the kidneys in pregnant rats, especially when they are overlapped, so they must be avoided during pregnancy to maintain kidney health.