Radioactive imagine agents : 99mTc-toxicological study
Author
Source
Iraqi Journal of Industrial Research
Issue
Vol. 9, Issue 1 (30 Jun. 2022), pp.120-137, 18 p.
Publisher
Ministry of Industry and Minerals Corporation of Research and Industrial Development
Publication Date
2022-06-30
Country of Publication
Iraq
No. of Pages
18
Main Subjects
Topics
Abstract EN
Radioactive pharmaceutical materials (radiopharmaceuticals) that contain radioactive atom or/ and ion (emits nuclear (α, β, or / and γ) ray according to its energy and half-life duration) companied with organic or inorganic molecule are important materials in nuclear imaging or therapeutically medicine.
Many biomolecules labeled with Technetium-99 in relationship to toxicity issues can be transported, distributed, and detected with the computerized algorithm detector depending upon chemical, biological, metabolic, and functional properties of tissue or organ (bone, liver, heart, kidney, and others).
According to literatures' review about this subject, this is the first try in Iraq and other countries to study Technetium – radiomolecules with in Silico depending on two approachs.
LD50, Class, Polar Surface Area PSA, logP, Hepatotoxicity, Carcinogenity, Immunotoxicity, Mutagenicity, Cytotoxicity, AMES test, Max.
tolerated dose (human), hERG I and II inhibitor, Oral Rat Acute (LD50) and Chronic (LOAEL) Toxicity, Hepatotoxicity besides Skin Sensitisation showed that Tc-biomolecules under study are structurally unsafe having toxic response to liver, immune system, cellular components, DNA, and/or cardiac repolarization through hERG inhibition of action.
These mainly conclusion notes depended upon Technetium oxidation state, heteroatoms presence, surface properties besides bio-target specifications, concentration, exposure time, genetic factors of human, and health problems.
American Psychological Association (APA)
Hammud, Kifaa Khalaf. 2022. Radioactive imagine agents : 99mTc-toxicological study. Iraqi Journal of Industrial Research،Vol. 9, no. 1, pp.120-137.
https://search.emarefa.net/detail/BIM-1381191
Modern Language Association (MLA)
Hammud, Kifaa Khalaf. Radioactive imagine agents : 99mTc-toxicological study. Iraqi Journal of Industrial Research Vol. 9, no. 1 (2022), pp.120-137.
https://search.emarefa.net/detail/BIM-1381191
American Medical Association (AMA)
Hammud, Kifaa Khalaf. Radioactive imagine agents : 99mTc-toxicological study. Iraqi Journal of Industrial Research. 2022. Vol. 9, no. 1, pp.120-137.
https://search.emarefa.net/detail/BIM-1381191
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 135-137
Record ID
BIM-1381191