Association of common variants of FGF21 Gene Polymorphism Rs499765 and Rs838133 with type 2 diabetes mellitus in Iraqi population
Other Title(s)
ترافق المتغيرات الشائعة لانماط الوراثية (Rs499765 و Rs838133) لجين FGF21 لدى العراقيين المصابين بداء السكري من النوع الثاني
Joint Authors
al-Kayshawan, Dhikrah Abd Jabr
al-Janabi, Abd al-Husayn A. F.
Abbud, Rasha Muhammad
Husayn, Majid Kazim
Source
Issue
Vol. 22, Issue 2 (31 Dec. 2021), pp.27-40, 14 p.
Publisher
University of Thi-Qar College of Medicine
Publication Date
2021-12-31
Country of Publication
Iraq
No. of Pages
14
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Abstract EN
Background: Type 2 diabetes mellitus is a major public health issue.
FGF21 is a key endocrine regulating protein factor involved in ontogenesis and metabolism.
Aim: To assess the association of FGF21 gene polymorphism (rs499765 and rs838133) in Iraqi type 2 diabetic patients.
Methods: To assess the relationship between SNPs (rs499765 and rs838133) of the FGF21 gene and T2DM, a case-control study of 200 people (100 T2DM and 100 controls) was undertaken.
Tetra ARMS- PCR was used to genotype SNPs (rs499765 and rs838133) using specified primers after extracting DNA from blood.
Various statistical analyses were used to analyze the results.
Results: The differences in total cholesterol, VLDL, TG and HDL between healthy and diabetic groups are significant.
Genotyping of FGF21 gene for rs838133 SNP revealed a significant elevation of the number of the AC carriers in the patient's group versus the controls group under the co-dominant model, the dominant model and the over dominant were significantly increased the risk of T2DM by 1.91, 1.8 and 1.94 folds (OR=1.91, P=0.0320), (OR=1.87, P=0.037) and (OR=1.94, P=0.0270) respectively.
The analysis of the rs499765 SNP failed to exhibit a significant variation under all examined inheritance models.
Conclusion: Carriers of the AC genotype of rs838133 SNP in FGF21 gene have a 1.9 folds risk to develop T2DM in comparison to those of the wild genotype, rs499765 (C>G), is not linked to the T2DM in the Iraqi population.
American Psychological Association (APA)
al-Janabi, Abd al-Husayn A. F.& Husayn, Majid Kazim& al-Kayshawan, Dhikrah Abd Jabr& Abbud, Rasha Muhammad. 2021. Association of common variants of FGF21 Gene Polymorphism Rs499765 and Rs838133 with type 2 diabetes mellitus in Iraqi population. Thi-Qar Medical Journal،Vol. 22, no. 2, pp.27-40.
https://search.emarefa.net/detail/BIM-1382037
Modern Language Association (MLA)
al-Janabi, Abd al-Husayn A. F.…[et al.]. Association of common variants of FGF21 Gene Polymorphism Rs499765 and Rs838133 with type 2 diabetes mellitus in Iraqi population. Thi-Qar Medical Journal Vol. 21, no. 2 (2021), pp.27-40.
https://search.emarefa.net/detail/BIM-1382037
American Medical Association (AMA)
al-Janabi, Abd al-Husayn A. F.& Husayn, Majid Kazim& al-Kayshawan, Dhikrah Abd Jabr& Abbud, Rasha Muhammad. Association of common variants of FGF21 Gene Polymorphism Rs499765 and Rs838133 with type 2 diabetes mellitus in Iraqi population. Thi-Qar Medical Journal. 2021. Vol. 22, no. 2, pp.27-40.
https://search.emarefa.net/detail/BIM-1382037
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 39
Record ID
BIM-1382037