Changes in coagulation status in patients with β-thalassemia in Iraq : a case-control study
Joint Authors
Wadaha, Husayn Abd al-Zahrah
Khamis, Muhammad Hasib
Meshay, Hasan Didi
Source
Issue
Vol. 19, Issue 2 (30 Jun. 2022), pp.157-161, 5 p.
Publisher
University of Babylon College of Medicine
Publication Date
2022-06-30
Country of Publication
Iraq
No. of Pages
5
Main Subjects
Topics
Abstract EN
Background : the pathogenesis β-thalassemia is characterized by anemia resulting from reduced β-globin synthesis with low hemoglobin a (HbA) production and higher production of hemoglobin A2 (HbA2) and fetal hemoglobin (HbF).
however, thromboembolic events have been recently identified in patients with β-thalassemia due to hypercoagulable state.
Objectives : the aim of this study was to evaluate the levels of some coagulation markers in Iraqi patients with β-thalassemia major and β-thalassemia intermedia.
materials and methods : the study included three groups.
the first group included patients with β-thalassemia major (n = 39), the second group included patients with β-thalassemia intermedia (n = 11), and third group included 20 apparently healthy control subjects.
each of prothrombin time (PT), activated partial thromboplastin time (APTT), antithrombin III (ATIII), and thrombin-antithrombin III (TAT) complex were measured according to the standard protocols.
results : both PT and APTT in β-thalassemia major and β-thalassemia intermedia were higher than that of the control group with a highly significant difference (P = 0.002), whereas no significant differences were observed between patients with β-thalassemia major and β-thalassemia intermedia.
mean ATIII level was highest in the control group followed by β-thalassemia intermedia and then by β-thalassemia major groups (P < 0.001), whereas mean TAT complex was highest in thalassemia major group followed by β-thalassemia intermedia and then by control groups (P < 0.001).
conclusions : prolonged PT and APTT in patients with β-thalassemia together with the reduction in the level of anticoagulant factor (ATII) suggest a role for liver impairment ; however, the significantly higher TAT complex is suggestive of ongoing activation of coagulation cascade in patients with β-thalassemia.
American Psychological Association (APA)
Wadaha, Husayn Abd al-Zahrah& Meshay, Hasan Didi& Khamis, Muhammad Hasib. 2022. Changes in coagulation status in patients with β-thalassemia in Iraq : a case-control study. Medical Journal of Babylon،Vol. 19, no. 2, pp.157-161.
https://search.emarefa.net/detail/BIM-1382304
Modern Language Association (MLA)
Wadaha, Husayn Abd al-Zahrah…[et al.]. Changes in coagulation status in patients with β-thalassemia in Iraq : a case-control study. Medical Journal of Babylon Vol. 19, no. 2 (Apr. / Jun. 2022), pp.157-161.
https://search.emarefa.net/detail/BIM-1382304
American Medical Association (AMA)
Wadaha, Husayn Abd al-Zahrah& Meshay, Hasan Didi& Khamis, Muhammad Hasib. Changes in coagulation status in patients with β-thalassemia in Iraq : a case-control study. Medical Journal of Babylon. 2022. Vol. 19, no. 2, pp.157-161.
https://search.emarefa.net/detail/BIM-1382304
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 161
Record ID
BIM-1382304