The association of resistin levels with resistance to insulin in Iraqi type 2 diabetes mellitus patients

Abstract EN

Resistin, is suggested as an important factor in pathogenesis of insulin resistance associated with obesity, and so might lead to development to T2DM.

We want to verify the correlation between resistin and glycaemic parameters and marker of obesity in Iraq T2DM patients.

Aims: To test the association of resistin with BMI and insulin resistance in T2DM.

Methods: In this study 400 participant’s was included divided in to two groups (200) T2DM patients and (200) healthy control persons.

The biochemical and anthropometric parameters included are body mass index (BMI), fasting resistin level, fasting blood glucose (FBG) ,HOMA-IR and fasting insulin level.

Results : The positively significant correlation between resistin and BMI (r = 0.939, p<0.0001), insulin (r = 0.917, p < 0.0001), FBS(r = 0.966, p<0.0001) and HOMA-IR (r = 0.947, p<0.0001) in T2DM were noted.

Conclusion : Resistin might be consider as potent link between obesity, insulin resistance and diabetes through disruption the signaling pathway of insulin that may lead to development of insulin resistance and diabetes.