The diabetes mellitus incidence in recipients of renal allograft in al-Nassiyria city

Abstract EN

BACKGROUND: Immunosuppressive drugs is the main cause of Post-transplant diabetes mellitus, which consider as one of the highly commonest transplant complications.

Aim: To assess the Post-transplant diabetes mellitus incidence and determine the other factors which may play a role in this complication development.

Method: 105 non-DM study population included in this study transplanted renal allograft, since 1999.

Post-transplant diabetes mellitus was identified by the requirement of the hypoglycemic drug which started after transplantation by a range of more than one month.

All patients after transplantation received prednisone and cyclosporine and no one received tacrolimus.

Results: At 1st, 3rd, 5th, and 10th years follow up after transplantation, five, eight, eleven and lastly nineteen percent developing Post-transplant diabetes mellitus., the correlated variables was determined as independent variables for the rapid increment in the Post-transplant diabetes mellitus numbers, which, higher BMI- before transplant, age of recipient the younger than 45 years significantly differ from older age with P < 0.0001 Conclusions: Post-transplant diabetes mellitus risk continuously increases with post-transplant time.

Transplanted patients show increment in Post-transplant diabetes mellitus incidence whose recipients characteristics changes is the full explanation of this matter.

The assumption of a cause of this increment is due to the introduction of better absorbed CsA formulations, which resulted in higher diabetogenic drug cumulative exposure in addition to other factors.