Relation between visfatin, body mass index with insulin resistance in type 2 diabetic Iraqi patients

Abstract EN

Background: Insulin resistance, obesity, sedentary lifestyle and type of food are considered to be a causative agent for predisposing of T2DM.

Aim: To investigate the correlation between insulin resistance with BMI and the effect of Visfatin in this interaction (T2DM).

Method: This project has two groups, a control healthy group consist of 200 volunteers and a second group of 200 T2DM patients who were documented according to WHO criteria.

HOMA-IR, FBG and BMI were measured.

Results: A significant relationship between T2DM and IR was observed, additionally to a significant relationship between visfatin level and blood glucose level.

Conclusion: T2DM is associated with insulin resistance which has many predisposing factors like obesity, sedentary lifestyle and type of food style, visfatin is an adipokine with an insulin-mimetic action that tends to increase insulin sensitivity and reduces blood glucose level and this clarifies the elevated level of Visfatin in such T2DM.