Urokinase type plasminogen activator receptor expression in colorectal neoplasms
Other Title(s)
دراسة مستقبل منشط إنزيم يوروكاينيس بلازمانوجين في سرطان القولون و المستقيم
Author
al-Jawhar, Rasha Qusayy Abd al-Ghani
Source
Issue
Vol. 20, Issue 2 (31 Dec. 2020), pp.208-218, 11 p.
Publisher
University of Thi-Qar College of Medicine
Publication Date
2020-12-31
Country of Publication
Iraq
No. of Pages
11
Main Subjects
Abstract EN
Background-The urokinase type plasminogen activator receptor (uPAR) may play a critical role in cancer invasion and metastasis.
Aims-To study the involvement of uPAR in colorectal carcinogenesis.
Methods-fourty four cases of colorectal adenocarcinoma were obtained and diagnosed as colonic carcinoma with it's grade received as formalin-fixed, paraffin-embedded tissue in AL-Nasiriyah teaching hospital with cases of carcinoma also 6 cases of normal endoscopic biopsies used as control –ve and 10 cases of adenoma with dysplastic changes all these cases stain by immunohistochemical methods for expression and localisation of uPAR.
Results_ all the cases of endoscopic biopsies were –ve for these receptors so used as –ve control, while cases of adenoma 3 out of 10 cases showing focal positivity in areas of dysplasia, while the cases of invasive carcinoma showing diffused positivity and the case percent of positivity depend on grade so high grade tumor showing a high percentage of positivity.
Conclusions-Colorectal adenoma uPAR, expressed essentially in dysplastic epithelial cells, was upregulated with increasing severity of atypia, and increased notably during the critical transition from severe dysplasic adenoma to invasive carcinoma.
These findings implicate uPAR expression in the invasive and metastatic processes of colorectal cancer.
American Psychological Association (APA)
al-Jawhar, Rasha Qusayy Abd al-Ghani. 2020. Urokinase type plasminogen activator receptor expression in colorectal neoplasms. Thi-Qar Medical Journal،Vol. 20, no. 2, pp.208-218.
https://search.emarefa.net/detail/BIM-1384803
Modern Language Association (MLA)
al-Jawhar, Rasha Qusayy Abd al-Ghani. Urokinase type plasminogen activator receptor expression in colorectal neoplasms. Thi-Qar Medical Journal Vol. 20, no. 2 (2020), pp.208-218.
https://search.emarefa.net/detail/BIM-1384803
American Medical Association (AMA)
al-Jawhar, Rasha Qusayy Abd al-Ghani. Urokinase type plasminogen activator receptor expression in colorectal neoplasms. Thi-Qar Medical Journal. 2020. Vol. 20, no. 2, pp.208-218.
https://search.emarefa.net/detail/BIM-1384803
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 216-217
Record ID
BIM-1384803