Decreased ABCG2 expression in prostate cancer and negatively associated with poorly differentiated grade and biochemical recurrence
Other Title(s)
انخفاض تعبير معلم (ABCG2) في سرطان البروستاتا و ارتباطه سلبا مع مرحله التميز لخلايا سرطان البروستاتا و الانتكاس
Joint Authors
al-Ghazzi, Zafir Abd Allah Farhan
Whitley, Paul
Beresford, Mark
Bowen, Rebecca
Mitchard, John
Chalmers, Andrew D.
Source
Issue
Vol. 20, Issue 2 (31 Dec. 2020), pp.242-256, 15 p.
Publisher
University of Thi-Qar College of Medicine
Publication Date
2020-12-31
Country of Publication
Iraq
No. of Pages
15
Main Subjects
Telecommunications Engineering
Medicine
Abstract EN
Summary Few prognostic biomarkers have been identified for prostate cancer and there are clinical difficulties in distinguishing between relapsing and non-relapsing diseases.
The aim of this study is to investigate the hypothesis that ABCG2 might be a potential biomarker for prostate cancer and could distinguish between aggressive tumours requiring radical intervention and those that have a good prognosis.
ABCG2 is a transmembrane protein that plays a vital role in promoting proliferation and maintaining the undifferentiated phenotype of stem cells.
It is thought to be a potential biomarker that can predict clinical progression and prognosis of different kinds of tumors.
However, its role in prostate tumor remains unclear.
Nuclear and cytoplasmic ABCG2 staining has been evaluated by immunohistochemistry using two sources of patient samples.
The tissue microarray group consists of 96 cases including normal, adjacent normal and malignant prostate tissue samples.
The Bath cohort consists of 30 samples, including samples from patients that had recurrent disease and those who remained disease-free.
The immunohistochemical study showed nuclear and cytoplasmic ABCG2 expression in benign and malignant prostate samples.
Cytoplasmic ABCG2 expression was also significantly reduced in prostate cancer compared to normal tissues.
Cytoplasmic ABCG2 staining was negatively associated with increasing Gleason grade.
In the Bath cohort, there was a negative association between ABCG2 expression and biochemical relapse.
This preliminary data showed that ABCG2 might play a role in cancer formation and/or aggressiveness and warrants further investigation to understand its function and establish if it could be a potential diagnostic biomarker for prostate tumour.
American Psychological Association (APA)
al-Ghazzi, Zafir Abd Allah Farhan& Whitley, Paul& Beresford, Mark& Bowen, Rebecca& Mitchard, John& Chalmers, Andrew D.. 2020. Decreased ABCG2 expression in prostate cancer and negatively associated with poorly differentiated grade and biochemical recurrence. Thi-Qar Medical Journal،Vol. 20, no. 2, pp.242-256.
https://search.emarefa.net/detail/BIM-1384827
Modern Language Association (MLA)
al-Ghazzi, Zafir Abd Allah Farhan…[et al.]. Decreased ABCG2 expression in prostate cancer and negatively associated with poorly differentiated grade and biochemical recurrence. Thi-Qar Medical Journal Vol. 20, no. 2 (2020), pp.242-256.
https://search.emarefa.net/detail/BIM-1384827
American Medical Association (AMA)
al-Ghazzi, Zafir Abd Allah Farhan& Whitley, Paul& Beresford, Mark& Bowen, Rebecca& Mitchard, John& Chalmers, Andrew D.. Decreased ABCG2 expression in prostate cancer and negatively associated with poorly differentiated grade and biochemical recurrence. Thi-Qar Medical Journal. 2020. Vol. 20, no. 2, pp.242-256.
https://search.emarefa.net/detail/BIM-1384827
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 253-255
Record ID
BIM-1384827