Mutational analysis of the Janus kinase II (V617F) gene in patients with β-Thalassemia major
Author
Source
ZANCO Journal of Pure and Applied Sciences
Issue
Vol. 32, Issue 6 (31 Dec. 2020), pp.72-75, 4 p.
Publisher
Salahaddin University-Erbil Department of Scientific Publications
Publication Date
2020-12-31
Country of Publication
Iraq
No. of Pages
4
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Abstract EN
β-Thalassemia is a group of congenital hemolytic anemia that characterized by the underproduction of the indispensable hemoglobin molecule, the oxygen and carbon dioxide carrying protein inside the red cells.
With our current study, we’ve screened if some extent mutation at Valine 617 Phenylalanine of Janus kinase II genes detectable in β-thalassemia major in our region.
The present study for the screening of JAK II V617F mutation was conducted on (50) patients with β-thalassemia major, restriction fragment length polymorphism with restriction endonuclease enzyme AflIII was used to identify a flaking region of 617 for JAK II gene.
In the existing study, no mutation has been detected within the patients suffering from β-thalassemia major.
Our results indicate that JAK II V617F mutation appears to not be associated with thromboembolic complications related to β-Thalassemia and therefore the incidence of β-Thalassemia.
To the bet of our knowledge, this study is the first evidence to determine the status of JAK II V617F mutation in patients with Thalassemia major in our region and expands the international published literature on.
American Psychological Association (APA)
Ahmad, Salar A.. 2020. Mutational analysis of the Janus kinase II (V617F) gene in patients with β-Thalassemia major. ZANCO Journal of Pure and Applied Sciences،Vol. 32, no. 6, pp.72-75.
https://search.emarefa.net/detail/BIM-1385427
Modern Language Association (MLA)
Ahmad, Salar A.. Mutational analysis of the Janus kinase II (V617F) gene in patients with β-Thalassemia major. ZANCO Journal of Pure and Applied Sciences Vol. 32, no. 6 (2020), pp.72-75.
https://search.emarefa.net/detail/BIM-1385427
American Medical Association (AMA)
Ahmad, Salar A.. Mutational analysis of the Janus kinase II (V617F) gene in patients with β-Thalassemia major. ZANCO Journal of Pure and Applied Sciences. 2020. Vol. 32, no. 6, pp.72-75.
https://search.emarefa.net/detail/BIM-1385427
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 75
Record ID
BIM-1385427