Protective roles of melatonin on hematological parameters and thyroid hormone levels in rats treated with aluminum chloride

Abstract EN

Background: Aluminum exists in numerous produced foods, medicines and likewise added to drinking water for refining purpose.

Its existence has so heavily contaminated with the surroundings that exposed to it is almost inescapable.

Goal: This survey was aimed at evaluating effect of Melatonin for inhibiting effect of Aluminum Chloride.

Methods: Randomly selected rats were grouped separately into three groups for 40 days: (n = 5/group): healthy key group, Aluminum Chloride (AlCl3) group (Urged with 1000mg/L of AlCl3 in administrated water) and The last group were awarded (1000mg/L) of AlCl3 in water plus melatonin (50mg/kg diet).

The estimated haematological parameters were leukocytes, erythrocytes, haemoglobin concentration and thrombocytes count.

Also serum and brain supernatant beta amyloid and serum levels of T3, T4 and TSH were also measured.

Results: At the end of this study, statistical analysis showed that the some haematological parameters (RBC count Hb, PCV, WBC count, granulocyte and lymphocyte differential leucocyte counts, platelet count) serum and brain beta amyloid and thyroid hormone values in AlCl3 with melatonin at a dosage of 50mg/kg diet has aroused the rats to stay approximately near to the standards.

Conclusion: From the results of this study it was discovered that melatonin has a therapeutic effect on AlCl3 induced in albino rats.