Protective roles of melatonin on hematological parameters and thyroid hormone levels in rats treated with aluminum chloride
Author
Source
ZANCO Journal of Pure and Applied Sciences
Issue
Vol. 32, Issue 6 (31 Dec. 2020), pp.76-86, 11 p.
Publisher
Salahaddin University-Erbil Department of Scientific Publications
Publication Date
2020-12-31
Country of Publication
Iraq
No. of Pages
11
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Abstract EN
Background: Aluminum exists in numerous produced foods, medicines and likewise added to drinking water for refining purpose.
Its existence has so heavily contaminated with the surroundings that exposed to it is almost inescapable.
Goal: This survey was aimed at evaluating effect of Melatonin for inhibiting effect of Aluminum Chloride.
Methods: Randomly selected rats were grouped separately into three groups for 40 days: (n = 5/group): healthy key group, Aluminum Chloride (AlCl3) group (Urged with 1000mg/L of AlCl3 in administrated water) and The last group were awarded (1000mg/L) of AlCl3 in water plus melatonin (50mg/kg diet).
The estimated haematological parameters were leukocytes, erythrocytes, haemoglobin concentration and thrombocytes count.
Also serum and brain supernatant beta amyloid and serum levels of T3, T4 and TSH were also measured.
Results: At the end of this study, statistical analysis showed that the some haematological parameters (RBC count Hb, PCV, WBC count, granulocyte and lymphocyte differential leucocyte counts, platelet count) serum and brain beta amyloid and thyroid hormone values in AlCl3 with melatonin at a dosage of 50mg/kg diet has aroused the rats to stay approximately near to the standards.
Conclusion: From the results of this study it was discovered that melatonin has a therapeutic effect on AlCl3 induced in albino rats.
American Psychological Association (APA)
al-Marzani, Zrar Salim Karim. 2020. Protective roles of melatonin on hematological parameters and thyroid hormone levels in rats treated with aluminum chloride. ZANCO Journal of Pure and Applied Sciences،Vol. 32, no. 6, pp.76-86.
https://search.emarefa.net/detail/BIM-1385430
Modern Language Association (MLA)
al-Marzani, Zrar Salim Karim. Protective roles of melatonin on hematological parameters and thyroid hormone levels in rats treated with aluminum chloride. ZANCO Journal of Pure and Applied Sciences Vol. 32, no. 6 (2020), pp.76-86.
https://search.emarefa.net/detail/BIM-1385430
American Medical Association (AMA)
al-Marzani, Zrar Salim Karim. Protective roles of melatonin on hematological parameters and thyroid hormone levels in rats treated with aluminum chloride. ZANCO Journal of Pure and Applied Sciences. 2020. Vol. 32, no. 6, pp.76-86.
https://search.emarefa.net/detail/BIM-1385430
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 84-86
Record ID
BIM-1385430