Evaluation of bioactivity of maximal inhibitory concentration of alkaloids isolated from mentha spicata leaves against some pathogenic fungi

Abstract EN

Alkaloids were isolated and identified from mentha spicata leaves.

qualitative analysis, thin layer chromatography(TLC), functional groups test and infra-red spectrum were carried out for identification of these alkaloids.

TLC results showed presence of two alkaloidic compounds in alkaloids extract.

the bioactivity and biochemical effect of alkaloids, was investigated towards four pathogenic fungi.

the maximal inhibitory concentration was measured to be (250 mg/ml) and the Bioactivity of this concentration was recorded against pathogenic fungi represented by aspergillus fumigatus, candida albicans, penicillum crysosporm and aspergillus niger with inhibition zone diameters equal to (23, 15, 15 and 11 mm) respectively.

Therefore, the alkaloidic compounds isolated can be used as an herbal theuraputic substituent to the different diseases caused by these fungi but this work demands further clinical and pharmaceutical studies.