Relationship between C-reactive protein, differential leukocyte count and uric acid in kidney disease in Erbil teaching hospital

Joint Authors

Ibrahim, Kharman Said
Haydar, Zhian Shirzad
Ibrahim, Abd Allah Said

Source

ZANCO Journal of Pure and Applied Sciences

Publisher

Salahaddin University-Erbil Department of Scientific Publications

Publication Date

2017-08-31

Country of Publication

Iraq

No. of Pages

9

Main Subjects

Biology

English Abstract

The study purpose was to evaluate the relationship between CRP, differential leukocyte count and uric acid in people with and without chronic kidney disease (CKD).

A case- control study carried out at kidney disease unite, Erbil teaching hospital, from June 2013 till November 2013.

Patient with diagnosed CKD being included with regular follow-up with no evidence of infection at time of interview by history, clinical examination and investigations including renal function testing, serum uric acid, CRP, general urine examination and other relevant investigations .The control group in general population were apparently healthy evaluated by the same way.

There was significant reduction (p<0.001) in lymphocyte level (12.52± 0.94) compared to control group (26.0±0.84) and significant increase was observed for CRP (10.56±0.61 ng/mL) in CKD patients compared with the control group (3.36±0.69 ng/mL) at the level (p<0.001).Serum uric acid was significantly high in patients with CKD (7.05±0.205 mg/mL) when compared to controls (4.3±0.27 mg/mL) at the level (p< 0.001).Lymphocyte count showed significant reduction (p<0.001) (12.93± 0.86) and (13.46± 0.84) compared to control group (25.2±1.45) and (26.35± 0.7) respectively, while other differential leukocyte count show no significant difference when compared with control group.

CRP negatively and significantly correlated with lymphocyte level (-0.626), while serum CRP level positively correlated with neutrophil level (0.547) and monocyte level (0.291).

Also serum uric acid negatively and significantly correlated with lymphocyte level (-0.530), and positively correlated with neutrophil level (0.450) and monocyte level (0.236).

Compared with those without CKD, patients with CKD have more eosinophil and granulocytes, CRP, uric acid and fewer lymphocytes.

Hyperuricemia is a valuable predictor of a GFR decrease, early detection and prevention on hyperuricemia in CKD subjects are critical.

Data Type

Conference Papers

Record ID

BIM-1388812

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