Kinetic study of lornoxicam hydrolysis
Joint Authors
Amin, Dana Muhammad Hamad
Amin, Sawsan Hasan Hammudi
Source
ZANCO Journal of Pure and Applied Sciences
Issue
Vol. 32, Issue 1 (29 Feb. 2020), pp.65-74, 10 p.
Publisher
Salahaddin University-Erbil Department of Scientific Publications
Publication Date
2020-02-29
Country of Publication
Iraq
No. of Pages
10
Main Subjects
Abstract EN
Gastrointestinal tract (GIT) side effects due to the local action of lornoxicam considered the most common problem that associated with using of this analgesic drug.
Masking of the enolic alcohol OH group of lornoxicam to overcoming this problem was the aim, however, applying Williamson ether synthesis led to amide hydrolysis.
Therefore, the objective of this study was shifted to study the hydrolytic kinetics and the influence of different bases as a function of time and temperature in the reaction media.
The effects of all bases used in the study on the hydrolysis process of lornoxicam have been studied; NaOH was found to be the strongest followed by Na2CO3 and K2CO3.
All three temperatures (25°C, 50°C and 80°C) have approximately similar effect except reflux condition that accelerates the hydrolysis process compare with the others.
The hydrolysis process is proportional with time.
Williamson ether synthetic procedure that followed to synthesize lornoxicam prodrugs was failed despite attempting different conditions.
Using bases were induced the hydrolysis process of lornoxicam.
The hydrolysis rate accelerated under reflux more than other conditions.
In addition, reaction time gives more hydrolysis process.
American Psychological Association (APA)
Amin, Sawsan Hasan Hammudi& Amin, Dana Muhammad Hamad. 2020. Kinetic study of lornoxicam hydrolysis. ZANCO Journal of Pure and Applied Sciences،Vol. 32, no. 1, pp.65-74.
https://search.emarefa.net/detail/BIM-1389381
Modern Language Association (MLA)
Amin, Sawsan Hasan Hammudi& Amin, Dana Muhammad Hamad. Kinetic study of lornoxicam hydrolysis. ZANCO Journal of Pure and Applied Sciences Vol. 32, no. 1 (2020), pp.65-74.
https://search.emarefa.net/detail/BIM-1389381
American Medical Association (AMA)
Amin, Sawsan Hasan Hammudi& Amin, Dana Muhammad Hamad. Kinetic study of lornoxicam hydrolysis. ZANCO Journal of Pure and Applied Sciences. 2020. Vol. 32, no. 1, pp.65-74.
https://search.emarefa.net/detail/BIM-1389381
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 73-74
Record ID
BIM-1389381