The effect of some beverage rich in chlorogenic acid on rats suffering from chronic liver damage induced by carbon tetrachloride

Abstract EN

Chronic liver disease refers to on-going inflammation in the liver for at least 6 months with the potential to progress to cirrhosis and end-stage liver disease.

In the present study, the effect of some beverage rich in chlorogenic acid on rats suffering from chronic liver induced by carbon tetrachloride (CCl4) was studied in Male albino rats.

Forty-two rats were divided into six groups.

Group 1: negative control group (normal, fed on basal diet), Group2: positive group, injected with CCl4 (fed on basal diet).

Groups 3, 4, 5 and 6 were injected with CCl4 co-administered with green coffee, roasted coffee, green tea and black tea.

The results showed that the administration of CCl4 resulted in significant increase in liver enzyme, in addition, CCl4 disturbed liver histology.

There was a statistically significant difference between the positive control group when compared to green coffee and green tea groups (192.33 ± 6.83 g vs.

193.67 ± 7.50 g, respectively) in the final weight.

Beverage extract has a beneficial effect on serum glucose, lipid profile, kidney, and liver function.

Histopathological examination indicated that groups administered with green tea, roasted coffee have normal histological structure.