Ameliorative impact of high inositol diet on the insulin resistance and metabolite hormones among women with polycystic ovary syndrome

Abstract EN

Polycystic ovary syndrome (PCOS) is the most prevalent endocrinopathy and metabolic condition in women of reproductive age.

inositol was shown to be effective in improving metabolic parameters in PCOS women due to its insulin-sensitizing impact.

the current study object to evaluate the impact of high inositol diet to manage insulin resistance of PCOS women.

control clinical trial was conducted on pcos women that divided into control group (cg) which described for their medication; inositol diet group (IDG) was preserved on high inositol diet (1500 mg / day per 1800 kcal); inositol supplement group (ISG) was supplemented with inositol capsule (2 g per day) and kept on high inositol diet.

combined group (IFG) was kept on high inositol diet, inositol capsule supplement and folic acid (400 μg per day), continued for 3 consecutive months.

the results indicated that majority of patients had mild degree of hirsutism, and the menstrual cycle occurred three times per year.

androgen hormones decreased significantly at (p ≤ 0.001) especially in IFG, that have the highest significant (p ≤ 0.001) impact by means 2.43 ± 0.19 and 56.00 ± 4.27 NMOL / l for total testosterone and sex hormone-binding globulin (SHBG).

luteinising hormone (LH) / follicle stimulating hormone (FSH) ratio was ameliorated significantly (p ≤ 0.001) that nearest to 1 in IFG, then ISG (1.19 ± 0.18) and IDG (1.36 ± 0.17) compared to cg (2.47 ± 0.34).

glycated hemoglobin ale (HGALC) was modulated considerably range between 5.49 ± 0.09 to 4.47 ± 0.36 for IDG and IFG.

high density lipoproteins (HDLC) were ameliorated at a high significant value (p ≤ 0.001) in ISG.

in conclusion, the findings proved that dietary management with high inositol diet improve insulin resistance and enhanced metabolic hormones of PCOS women.