Effect of helicobacter pylori infection on nutrition, metabolism, cognition, and serum vitamin B12 in the elderly

Abstract EN

Background : helicobacter pylori infection is one of the most common infections in humans.

the rate of H.

pylori infection and its complications is increasing with age worldwide.

many articles have published on the fascinating topic of extra-gastroduodenal manifestations of H.

pylori infection, most of which are commonly seen in the elderly population.

aim : to investigate the effect of H.

pylori infection on nutrition, metabolism, cognition, and serum vitamin B12 in the elderly.

subjects and methods : this study was conducted on 30 elderly patients with H.

pylori infection diagnosed by stool antigen test and 30 healthy control subjects matched for age, sex and socioeconomic status.

full history, complete physical examination, anthropometric measurements, laboratory parameters (routine laboratory investigation, metabolic parameters, serum iron level, serum vitamin B12 level), and HOMA-IR score.

moreover, all participants completed the mini mental state examination (MMSE) and mini nutritional assessment (MNA) questionnaires.

results : the results showed that patients with H.

pylori infection had significantly lower hemoglobin levels, lower serum iron levels, lower vitamin B12 levels, higher insulin levels, and higher prevalence of insulin resistance (defined as a HOMA-IR score ≥ 2.5).

there were no significant differences between the groups regarding the mean MMSE score, the mean MNA score, or the prevalence of metabolic syndrome according to the definition of the national cholesterol education program adult treatment panel III.

conclusion : H.

pylori seems to be associated with iron deficiency anemia, vitamin 12 deficiency and insulin resistance in the elderly.