Assessment of anti-inflammatory cytokine interleukin-10 in mild cognitive impairment in elderly
Joint Authors
Ramadan, Ali Mahmud Ali
Muhammad, Azzah Hasan
Arafah, Muhammad Husayn
Tahun, Muna Mustafa
Tahun, Kariman Abd al-Wahhab Abd al-Hayy
Source
NILES journal for Geriatric and Gerontology
Issue
Vol. 5, Issue 2 (30 Jun. 2022), pp.249-263, 15 p.
Publisher
Beni-Suef University National Institute of Longevity Elderly Sciences
Publication Date
2022-06-30
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Topics
Abstract EN
Background : mild cognitive impairment (MCI) is decline and disturbance of cognitive, little impairment of complex skills, ability to conduct ordinary daily functions, and the absence of dementia are all features of MCI.
interleukin-10 (IL-10) has anti-inflammatory effects and may suppress neurodegenerative disorders.
objective : this study aimed to investigate the possible association between serum interleukin 10 (IL-10) levels and mild cognitive impairment (MCI) in the elderly population.
material and methods : the study was carried out on 90 subjects aged 65 years or older] divided into group I (MCI patients) : including 45 patients.
in group II (control) : which included 45 subjects with normal cognition.
all subjects underwent detailed history taking, clinical examination, and assessment of cognitive function.
laboratory investigations included : serum interleukin-10 (IL-10), C-reactive protein (CRP), ESR, CBC, fasting blood glucose (FBS), postprandial blood glucose (PPS), UREA, creatinine, and liver enzyme levels.
results : IL-10 levels in the mci group ranged from 4.60–16.31 with a mean value (S.D) of 9.75 ± 2.26.
IL-10 among the control group ranged from 4.91–to 12.15 with a mean value (S.D) of 8.87 ± 1.80.
IL-10 was significantly higher among the mci group (p = 0.044) conclusion : there was a statistically significant difference between the serum levels of IL-10 in patients with MCI and controls.
American Psychological Association (APA)
Ramadan, Ali Mahmud Ali& Muhammad, Azzah Hasan& Tahun, Muna Mustafa& Tahun, Kariman Abd al-Wahhab Abd al-Hayy& Arafah, Muhammad Husayn. 2022. Assessment of anti-inflammatory cytokine interleukin-10 in mild cognitive impairment in elderly. NILES journal for Geriatric and Gerontology،Vol. 5, no. 2, pp.249-263.
https://search.emarefa.net/detail/BIM-1397881
Modern Language Association (MLA)
Ramadan, Ali Mahmud Ali…[et al.]. Assessment of anti-inflammatory cytokine interleukin-10 in mild cognitive impairment in elderly. NILES journal for Geriatric and Gerontology Vol. 5, no. 2 (2022), pp.249-263.
https://search.emarefa.net/detail/BIM-1397881
American Medical Association (AMA)
Ramadan, Ali Mahmud Ali& Muhammad, Azzah Hasan& Tahun, Muna Mustafa& Tahun, Kariman Abd al-Wahhab Abd al-Hayy& Arafah, Muhammad Husayn. Assessment of anti-inflammatory cytokine interleukin-10 in mild cognitive impairment in elderly. NILES journal for Geriatric and Gerontology. 2022. Vol. 5, no. 2, pp.249-263.
https://search.emarefa.net/detail/BIM-1397881
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 260-263
Record ID
BIM-1397881