Is treatment with oral or rectal misoprostol effective to prevent postpartum hemorrhage?
Other Title(s)
هل المعالجة بالميزوبروستول عم طريق الفم أو الشرج فعالة في الوقاية من النزف التالي للولادة ؟
Author
Source
Journal of the Arab Board of Health Specializations
Issue
Vol. 8, Issue 2 (31 May. 2006), pp.110-114, 5 p.
Publisher
The Arab Board of Health Specializations
Publication Date
2006-05-31
Country of Publication
Syria
No. of Pages
5
Main Subjects
Abstract AR
Objectives: To compare the efficacy of 400 mg of oral or rectal misoprostol with 0.2 mg intramuscular methylergometrine to prevent postpartum hemorrhage (PPH).
Methods : 672 women were randomized into three groups: Group 1 received 400 mg misoprostol orally (n - 240), Group 2 received 400 mg misoprostol rectally (n = 222), and Group 3 received 0.2 mg methylergometrine IM (n =210).
The mean blood loss, PPH > 500 ml, needs for additional oxytocic drugs, and decrease in hemoglobin concentration were the main outcomes measured.
Results: The demographic characteristics were comparable.
There were no significant differences among the three groups in mean blood loss (P = 0.112), incidence of PPH > 500ml (P=0.334), need for additional oxytocic agents fP=0.574), and decrease in mean hemoglobin concentration (P=0.613).
Significant differences detected with the use of misoprostol, whether given orally or rectally, were elevated temperature > 380 C (P= 0.002) and shivering (V=0.001).
Conclusion: Oral or rectal misoprostol is as effective as conventional, intramuscular methylergometrine in preventing postpartum hemorrhage, and the drug has the advantages of stability at room temperature and ease of administration.
It can be recommended for routine use anywhere for prevention of PPH
Abstract EN
Objectives: To compare the efficacy of 400 mg of oral or rectal misoprostol with 0.2 mg intramuscular methylergometrine to prevent postpartum hemorrhage (PPH).
Methods : 672 women were randomized into three groups: Group 1 received 400 mg misoprostol orally (n - 240), Group 2 received 400 mg misoprostol rectally (n = 222), and Group 3 received 0.2 mg methylergometrine IM (n =210).
The mean blood loss, PPH > 500 ml, needs for additional oxytocic drugs, and decrease in hemoglobin concentration were the main outcomes measured.
Results: The demographic characteristics were comparable.
There were no significant differences among the three groups in mean blood loss (P = 0.112), incidence of PPH > 500ml (P=0.334), need for additional oxytocic agents fP=0.574), and decrease in mean hemoglobin concentration (P=0.613).
Significant differences detected with the use of misoprostol, whether given orally or rectally, were elevated temperature > 380 C (P= 0.002) and shivering (V=0.001).
Conclusion: Oral or rectal misoprostol is as effective as conventional, intramuscular methylergometrine in preventing postpartum hemorrhage, and the drug has the advantages of stability at room temperature and ease of administration.
It can be recommended for routine use anywhere for prevention of PPH
American Psychological Association (APA)
al-Mumani, Murad. 2006. Is treatment with oral or rectal misoprostol effective to prevent postpartum hemorrhage?. Journal of the Arab Board of Health Specializations،Vol. 8, no. 2, pp.110-114.
https://search.emarefa.net/detail/BIM-140100
Modern Language Association (MLA)
al-Mumani, Murad. Is treatment with oral or rectal misoprostol effective to prevent postpartum hemorrhage?. Journal of the Arab Board of Health Specializations Vol. 8, no. 2(May 2006), pp.110-114.
https://search.emarefa.net/detail/BIM-140100
American Medical Association (AMA)
al-Mumani, Murad. Is treatment with oral or rectal misoprostol effective to prevent postpartum hemorrhage?. Journal of the Arab Board of Health Specializations. 2006. Vol. 8, no. 2, pp.110-114.
https://search.emarefa.net/detail/BIM-140100
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 113-114
Record ID
BIM-140100