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Efficacy of localized intradermal microinjection of tranexamic acid at a concentration of 4 mg-ml in the treatment of melasma in Syria
Other Title(s)
فعالية الحقن الدقيق الموضعي داخل الأدمة لحمض الترانكساميك بتركيز 4 ملغ-مل في علاج الكلف
Joint Authors
al-Mansur, Hibah Ghassan
Rumiyah, Abd al-Halim
Source
Journal of Medical and Pharmaceutical Sciences
Issue
Vol. 6, Issue 2 (30 Jun. 2022), pp.58-67, 10 p.
Publisher
Publication Date
2022-06-30
Country of Publication
Palestine (Gaza Strip)
No. of Pages
10
Main Subjects
Abstract EN
Background: Melasma is a common acquired hyperpigmented dermatosis due to a disorder in the function of the melanogenesis process.
Nowadays, there are many used treatments for melasma but it is still a big cosmetic problem.
The Aim of our study is to evaluate the efficacy and safety of intradermal microinjection of tranexamic acid TXA in the treatment of melasma in Syrian women.
Methods: A total of 34 women with melasma, attending Tishreen University Hospital in Lattakia-Syria from January 2020 to January 2021 were included in this prospective (before and after) study.
We applied topical anesthesia then we injected 0.05 ml TXA (4 mg/ml) intradermally into the melasma lesions at 1 cm intervals by using a 30-gauge insulin syringe.
We repeated this procedure every 2 weeks for 12 weeks.
A clinical investigator evaluated the results by using the modified Melasma Area and Severity Index (mMASI) at baseline and at 4, 8, and 12 weeks.
Patients were followed up after 3 months from completing the treatment.
Results: The mean mMASI scores decreased from 6.99±3.4 at baseline to 5.98±3.2, 4.59±2.5 and 3.49±2.3 at weeks 4, 8, 12 respectively.
This decrease was clinically and statistically significant with a p-value = 0.0001.
Our patients did not show serious side effects.
Conclusion: According to that, we suggest that localized intradermal microinjection of tranexamic acid at a concentration of 4 mg/ml is an effective and safe therapeutic method for melasma.
American Psychological Association (APA)
al-Mansur, Hibah Ghassan& Rumiyah, Abd al-Halim. 2022. Efficacy of localized intradermal microinjection of tranexamic acid at a concentration of 4 mg-ml in the treatment of melasma in Syria. Journal of Medical and Pharmaceutical Sciences،Vol. 6, no. 2, pp.58-67.
https://search.emarefa.net/detail/BIM-1406437
Modern Language Association (MLA)
al-Mansur, Hibah Ghassan& Rumiyah, Abd al-Halim. Efficacy of localized intradermal microinjection of tranexamic acid at a concentration of 4 mg-ml in the treatment of melasma in Syria. Journal of Medical and Pharmaceutical Sciences Vol. 6, no. 2 (Jun. 2022), pp.58-67.
https://search.emarefa.net/detail/BIM-1406437
American Medical Association (AMA)
al-Mansur, Hibah Ghassan& Rumiyah, Abd al-Halim. Efficacy of localized intradermal microinjection of tranexamic acid at a concentration of 4 mg-ml in the treatment of melasma in Syria. Journal of Medical and Pharmaceutical Sciences. 2022. Vol. 6, no. 2, pp.58-67.
https://search.emarefa.net/detail/BIM-1406437
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 65-67
Record ID
BIM-1406437