Efficacy and safety of intralesional injection of verapamil in treatment of keloids
Other Title(s)
فعالية و أمان علاج الجدرات بالفيراباميل حقنا ضمن الآفة
Joint Authors
Haydar, Ghufran Sayf al-Din
Khaddam, Jamal
Source
Journal of Medical and Pharmaceutical Sciences
Issue
Vol. 6, Issue 2 (30 Jun. 2022), pp.76-83, 8 p.
Publisher
Publication Date
2022-06-30
Country of Publication
Palestine (Gaza Strip)
No. of Pages
8
Main Subjects
Abstract EN
Objective: The aim of this study is to evaluate the efficacy of intralesional verapamil injection in treating keloids.
In addition to, assessment of side effects of the therapy.
Patients and Methods: A Prospective study (Before& After) conducted for the period one year (April 2020- April 2021) at Tishreen University Hospital in Lattakia- Syria.
30 patients with keloids who received treatment with verapamil were included in the study.
Results: The mean age was 22±6.3 years, 66.7% of patients were females.
Most common sites of keloids involvement were shoulders (46.7%), and acne vulgaris was the most frequently etiology (40%).
A statistically significantly reduction in the means of: Vancouver Scar Scale VSS 4.66±1.9 (day 21 of last treatment) vs.
7.06±1.8 (Day 0), p: 0.0001), height (1.16±0.6 vs.
2.23±0.6, p: 0.001), and pliability (1.33±0.9 vs.
2.60±0.6, p: 0.003), without recurrence of keloids at the day 90 of the last treatments.
Burning pain was the most side effect frequently seen (98%).There was no significant relationship between clinical improvement and each of the following: duration of disease and age of the patient (p>0.05).
Conclusion: Verapamil has significant therapeutic effects in decreasing the height of the lesion, improving pliability without recurrence of lesions or serious adverse effects, thus, it could be a safe choice in treatment of keloids.
American Psychological Association (APA)
Haydar, Ghufran Sayf al-Din& Khaddam, Jamal. 2022. Efficacy and safety of intralesional injection of verapamil in treatment of keloids. Journal of Medical and Pharmaceutical Sciences،Vol. 6, no. 2, pp.76-83.
https://search.emarefa.net/detail/BIM-1406439
Modern Language Association (MLA)
Haydar, Ghufran Sayf al-Din& Khaddam, Jamal. Efficacy and safety of intralesional injection of verapamil in treatment of keloids. Journal of Medical and Pharmaceutical Sciences Vol. 6, no. 2 (Jun. 2022), pp.76-83.
https://search.emarefa.net/detail/BIM-1406439
American Medical Association (AMA)
Haydar, Ghufran Sayf al-Din& Khaddam, Jamal. Efficacy and safety of intralesional injection of verapamil in treatment of keloids. Journal of Medical and Pharmaceutical Sciences. 2022. Vol. 6, no. 2, pp.76-83.
https://search.emarefa.net/detail/BIM-1406439
Data Type
Journal Articles
Language
English
Notes
Includes appendix : p. 83
Record ID
BIM-1406439