Docosahexaenoic acid activates the Nrf2 signaling pathway to alleviate impairment of spleen cellular immunity in intrauterine growth restricted rat pups
Joint Authors
Jiang, Weiming
Wan, Lijia
Chen, Pingyang
Lu, Wei
Source
Saudi Journal of Biological Sciences
Issue
Vol. 28, Issue 9 (30 Sep. 2021), pp.4987-4993, 7 p.
Publisher
Publication Date
2021-09-30
Country of Publication
Saudi Arabia
No. of Pages
7
Main Subjects
Abstract EN
Intrauterine growth retardation (IUGR) impairs immune function in children.
IUGR is associated with an imbalance of oxidative stress and abnormal apoptosis.
Therefore, an IUGR rats model was established to determine the antioxidant capacity and apoptosis in newborn IUGR rats and explored whether these effects were regulated after Docosahexaenoic acid (DHA) supplementation to rat pups.
First, eight normal-birth-weight (NBW) and eight IUGR neonatal rats (a 10% low-protein diet) were used to obtain the antioxidant capacity and apoptosis in IUGR rat pups.
Then, 32 newborn rats were randomly assigned to the normal birth weight (NBW), DHA supplementation for NBW (ND), IUGR, and DHA supplementation for IUGR (ID) groups.
Starting from the 7th day after birth, DHA was given to the experimental group and the same volume of distilled water was given to the control group for 21 days.
(1) DHA improved the serum and spleen CD4/CD8 ratios and IL-4 and IFN-γ mRNA expression.
(2) DHA decreased the level of MDA, but increased T-AOC in serum and spleen.
(3) DHA increased the protein expression of Bcl-2 while decreased Bax.
(4) DHA increased protein expression of the Nrf2 signaling pathway and the downstream antioxidant genes GSH-PX and CAT.
DHA may alleviate the impairment of spleen cellular immunity in IUGR rat pups by inhibiting oxidative stress and apoptosis related to the activation of Nrf2 signaling pathway.
American Psychological Association (APA)
Jiang, Weiming& Wan, Lijia& Chen, Pingyang& Lu, Wei. 2021. Docosahexaenoic acid activates the Nrf2 signaling pathway to alleviate impairment of spleen cellular immunity in intrauterine growth restricted rat pups. Saudi Journal of Biological Sciences،Vol. 28, no. 9, pp.4987-4993.
https://search.emarefa.net/detail/BIM-1410141
Modern Language Association (MLA)
Jiang, Weiming…[et al.]. Docosahexaenoic acid activates the Nrf2 signaling pathway to alleviate impairment of spleen cellular immunity in intrauterine growth restricted rat pups. Saudi Journal of Biological Sciences Vol. 28, no. 9 (2021), pp.4987-4993.
https://search.emarefa.net/detail/BIM-1410141
American Medical Association (AMA)
Jiang, Weiming& Wan, Lijia& Chen, Pingyang& Lu, Wei. Docosahexaenoic acid activates the Nrf2 signaling pathway to alleviate impairment of spleen cellular immunity in intrauterine growth restricted rat pups. Saudi Journal of Biological Sciences. 2021. Vol. 28, no. 9, pp.4987-4993.
https://search.emarefa.net/detail/BIM-1410141
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 4992-4993
Record ID
BIM-1410141