Exploring the therapeutic potential of Hibiscus rosa sinensis synthesized cobalt oxide (Co 3 O 4-NPs) and magnesium oxide nanoparticles (MgO-NPs)
Joint Authors
Khan, Muhammad Aslam
Rizwan, Muhammad
Kainat
Faysal, Shah
Zaman, Nasib
Afsheen, Zobia
Nadhir al-Din, Muhammad
Bibi, Nadiyah
Husayn, Zahid
Ali, Farhad
Source
Saudi Journal of Biological Sciences
Issue
Vol. 28, Issue 9 (30 Sep. 2021), pp.5157-5167, 11 p.
Publisher
Publication Date
2021-09-30
Country of Publication
Saudi Arabia
No. of Pages
11
Main Subjects
Abstract EN
Herein, we present a green, economic and ecofriendly protocol for synthesis of cobalt oxide (Co3O4-NPs) and magnesium oxide nanoparticles (MgO-NPs) for multifaceted biomedical applications.
In the study, a simple aqueous leaf extract of Hibiscus rosa sinensis, was employed for the facile one pot synthesis of Co3O4-NPs and MgO-NPs.
The well characterized NPs were explored for multiple biomedical applications including bactericidal activity against urinary tract infection (UTI) isolates, leishmaniasis, larvicidal, antidiabetic antioxidant and biocompatibility studies.
Our results showed that both the NPs were highly active against multidrug resistant UTI isolates as compared to traditional antibiotics and induced significant zone of inhibition against Proteus Vulgaris, Pseudomonas Aurigenosa and E.coli.
The NPs, in particular Co3O4-NPs also showed significant larvicidal activity against the Aedes Aegypti, the mosquitoes involve in the transmission of Dengue fever.
Similarly, excellent leishmanicidal activity was also observed against both the promastigote and amastigote forms of the parasite.
Furthermore, the particles also exhibited considerable antidiabetic activity by inhibiting α-amylase and α-glucosidase enzymes.
The biosynthesized NPs were found to be excellent antioxidant and biocompatible nanomaterials.
Owing to ecofriendly synthesis, non-toxic and biocompatible nature, the Hibiscus rosa sinensis synthesized Co3O4-NPs and MgO-NPs can be exploited as potential candidates for multiple biomedical applications.
American Psychological Association (APA)
Kainat& Khan, Muhammad Aslam& Ali, Farhad& Faysal, Shah& Rizwan, Muhammad& Husayn, Zahid…[et al.]. 2021. Exploring the therapeutic potential of Hibiscus rosa sinensis synthesized cobalt oxide (Co 3 O 4-NPs) and magnesium oxide nanoparticles (MgO-NPs). Saudi Journal of Biological Sciences،Vol. 28, no. 9, pp.5157-5167.
https://search.emarefa.net/detail/BIM-1410534
Modern Language Association (MLA)
Kainat…[et al.]. Exploring the therapeutic potential of Hibiscus rosa sinensis synthesized cobalt oxide (Co 3 O 4-NPs) and magnesium oxide nanoparticles (MgO-NPs). Saudi Journal of Biological Sciences Vol. 28, no. 9 (2021), pp.5157-5167.
https://search.emarefa.net/detail/BIM-1410534
American Medical Association (AMA)
Kainat& Khan, Muhammad Aslam& Ali, Farhad& Faysal, Shah& Rizwan, Muhammad& Husayn, Zahid…[et al.]. Exploring the therapeutic potential of Hibiscus rosa sinensis synthesized cobalt oxide (Co 3 O 4-NPs) and magnesium oxide nanoparticles (MgO-NPs). Saudi Journal of Biological Sciences. 2021. Vol. 28, no. 9, pp.5157-5167.
https://search.emarefa.net/detail/BIM-1410534
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 5166-5167
Record ID
BIM-1410534