Toxicological findings in a possible drug-drug interaction death : a case report
Other Title(s)
النتائج السمية في الوفيات المحتملة الناتجة عن التداخلات الدوائية : تقرير حالة
Joint Authors
Uraybi, Maqbul Isa
al-Bishi, Muhammad Yahya
Khardali, Ibrahim Abdu
al-Amir, Ahmad M.
Abu al-Sail, Farid Muhammad
Attafi, Ibrahim Muhammad
Source
Arab Journal of Forensic Sciences and Forensic Medicine
Issue
Vol. 3, Issue 1 (30 Jun. 2021), pp.128-133, 6 p.
Publisher
Naif Arab University for Security Sciences Arab Society for Forensic Sciences and Forensic Medicine
Publication Date
2021-06-30
Country of Publication
Saudi Arabia
No. of Pages
6
Main Subjects
Abstract EN
Synergistic effects are the most encountered types of drug-drug interaction in post-mortem toxicology.
Concomitant use of fentanyl, tramadol and carbamazepine may increase the risk of severe serotonin toxicity.
The decedent was a 32-year-old black man, with a history of severe migraine headaches.
He died after being administered several drugs to treat the migraine.
For fentanyl identification and quantification, samples were extracted using solid phase extraction and analyzed by GC-MS.
For carbamazepine and tramadol identification and quantification, samples were extracted by liquid-liquid extraction and analyzed by LC-QTOF.
Toxicology showed post-mortem concentrations of fentanyl 0.033, 0.025, 0.005, 0.0127, and 0.005 mg/L; tramadol 0.143, 0.093, 0.043, 0.09, and 0.08 mg/L; carbamazepine 1.6, 1.04, 0.3, 0.83, and 0.18 mg/L in the blood, brain, liver, kidney and stomach, respectively.
In this case report, the combination of serotonergic drugs can contribute to synergistic serotonergic effects.
Therefore, drug-drug interaction is expected, and the cause of death may be attributed to toxic synergistic drug-drug interaction including fentanyl, tramadol and carbamazepine
American Psychological Association (APA)
al-Bishi, Muhammad Yahya& Uraybi, Maqbul Isa& al-Amir, Ahmad M.& Khardali, Ibrahim Abdu& Abu al-Sail, Farid Muhammad& Attafi, Ibrahim Muhammad. 2021. Toxicological findings in a possible drug-drug interaction death : a case report. Arab Journal of Forensic Sciences and Forensic Medicine،Vol. 3, no. 1, pp.128-133.
https://search.emarefa.net/detail/BIM-1414309
Modern Language Association (MLA)
al-Bishi, Muhammad Yahya…[et al.]. Toxicological findings in a possible drug-drug interaction death : a case report. Arab Journal of Forensic Sciences and Forensic Medicine Vol. 3, no. 1 (2021), pp.128-133.
https://search.emarefa.net/detail/BIM-1414309
American Medical Association (AMA)
al-Bishi, Muhammad Yahya& Uraybi, Maqbul Isa& al-Amir, Ahmad M.& Khardali, Ibrahim Abdu& Abu al-Sail, Farid Muhammad& Attafi, Ibrahim Muhammad. Toxicological findings in a possible drug-drug interaction death : a case report. Arab Journal of Forensic Sciences and Forensic Medicine. 2021. Vol. 3, no. 1, pp.128-133.
https://search.emarefa.net/detail/BIM-1414309
Data Type
Journal Articles
Language
English
Notes
Record ID
BIM-1414309