Amlodipine polyamide-disulfide polymer as nanocomposites : preparation, characterizations and release study
Dissertant
Ahmad, Zayn al-Abidin Ghanim Ahmad
Thesis advisor
University
Isra University
Faculty
Faculty of Pharmacy
University Country
Jordan
Degree
Master
Degree Date
2021
Arabic Abstract
يهدف هذا البحث إلى استخدام الجسيمات النانوية كنظم لتوصيل الأدوية مع الاستفادة من الخصائص الاستثنائية للجسيمات النانوية، تهدف الدراسة الحالية إلى التحقق من تأثير البوليمر الجديد هو البولي أميد و روابط ثاني كبريتيد البوليمر بالإضافة إلى تركيزات كلوريد الحديد (Fecls) و كلوريد الألومنيوم (Alcls) على كفاءة تحميل عقار أملوديبين، و حجم الجسيمات، و إمكانات زينا، تم استكشاف هذا المركب النانوية في الدراسة الحالية بواسطة برنامج (مينتاب۱۸) 18 Minitab المستخدم و العديد من التحليلات الرسومية التابعة لهذا البرنامج.
و في النتيجة النهائية استخدمنا أملوديبين في هذه الدراسة كنموذج للدواء الذي تم تحميله على البوليمر الجديد.
لغرض التحسين التوافر البيولوجي و الامتصاص و الاستقرار و ملف تعريف إطلاق الدواء من خلال إعطاء إطالة ممتدة لأكثر من 24 ساعة و تأثير علاجي أفضل عن طريق تقليل الآثار الجانبية و تم دراسة جميع صفات الفيزيائية و الكيميائية لهذا المركب النانوية باستخدام العديد من الاجهزة و من ضمنها (FTIR) للأشعة تحت الحمراء و دراسة إطلاق الدواء في المختبر
English Abstract
This research aims to use polyamide-polysulfide nanoparticles as drug delivery systems.
The amlodipine (Amlop) was used as a model to form Amlop-Polymer nanocomposites.
In this work, we investigated the effect of independent variable (Polymer, Fe+3, Al+3, PH) on the dependent variable (% LE, Zeta potential, and Particle size).
During the preparation stage, various quantities of polymer (0.05, 0.125, and 0.2 gm), and FeCl3 and AlCl3 (0.6, 1.5 and 2.4 gm) and pH 6, 8, and 10 with the constant amount of Amlodipine of 0.1gm were used.
After obtained, these nanocomposites were characterized by Fourier Transform Infrared (FTIR) and vitro drug release study.
FTIR for nanocomposite shows a functional group of drug, which indicates encapsulation of Amlodipine into composite.
This nanocomposite was explored in the current study by using Minitab 18 software and numerous graphical analyses, which include half-normal plot, Pareto graph of the standardization impacts, residual plots including normal probability plots, versus order, versus Fits, Histogram, counter surface plots, and main effects and interaction plots.
Therefore, results indicated that Al, Fe, Polymer, PH, Al*Al, Al*Fe, Al*PH, Fe*Polymer are statistically significant at % LE.
For the particle size aspect, all eleven factors of data: Al*Fe, Al*Polymer, Polymer, PH, Al, Fe*PH, Al*Al, Al*PH, Fe*Polymer, Polymer*PH, Fe were statistically significant.
In addition, there are six factors that are statistically significant on zeta potential which are PH, Al*Al, Polymer, Al, Fe, and Fe*Polymer.
Results also indicated the (R2 ) value of LE % was 96.40%.
The R 2 value of Particle Size 95.65% and the R 2 value of zeta potential was 99.50%.
Due to the strong interaction between Amlop-Polymer with cross-linkers, we were able to create Amlop-Polymer nanocomposites with a suitable size range which was effective in carrying and preserving the drug as well as providing sustained release of encapsulated Amlop from final nanocomposite.
Main Subjects
No. of Pages
76
Table of Contents
Table of contents.
Abstract.
Abstract in Arabic.
Chapter One : Introduction.
Chapter Two : Literature review.
Chapter Three : Methodology.
Chapter Four : Results and discussion.
Chapter Five : Conclusions.
References.
American Psychological Association (APA)
Ahmad, Zayn al-Abidin Ghanim Ahmad. (2021). Amlodipine polyamide-disulfide polymer as nanocomposites : preparation, characterizations and release study. (Master's theses Theses and Dissertations Master). Isra University, Jordan
https://search.emarefa.net/detail/BIM-1414484
Modern Language Association (MLA)
Ahmad, Zayn al-Abidin Ghanim Ahmad. Amlodipine polyamide-disulfide polymer as nanocomposites : preparation, characterizations and release study. (Master's theses Theses and Dissertations Master). Isra University. (2021).
https://search.emarefa.net/detail/BIM-1414484
American Medical Association (AMA)
Ahmad, Zayn al-Abidin Ghanim Ahmad. (2021). Amlodipine polyamide-disulfide polymer as nanocomposites : preparation, characterizations and release study. (Master's theses Theses and Dissertations Master). Isra University, Jordan
https://search.emarefa.net/detail/BIM-1414484
Language
English
Data Type
Arab Theses
Record ID
BIM-1414484