Anti-HIV-1 reverse transcriptase property of some edible mushrooms in Asia
Joint Authors
Choengpanya, Khuanjarat
Ratanabunyong, Siriluk
Seetaha, Supaphorn
Tabtimmai, Lueacha
Choowongkomon, Kiattawee
Source
Saudi Journal of Biological Sciences
Issue
Vol. 28, Issue 5 (31 May. 2021), pp.2807-2815, 9 p.
Publisher
Publication Date
2021-05-31
Country of Publication
Saudi Arabia
No. of Pages
9
Main Subjects
Abstract EN
Human immunodeficiency virus (HIV) causes acquired immunodeficiency syndrome (AIDS), which is a serious health threat worldwide.
One of its core enzymes, reverse transcriptase (RT), is a target for HIV inhibition.
A number of bioactive compounds have been successfully used for HIV treatment.
However, HIV rapidly mutates, and long-term treatment can cause drug-resistant strains.
Therefore, new inhibitors are required to overcome this problem.
In this study, the aqueous, ethanolic and hexane crude extracts of 19 edible and medicinal mushrooms, which are widely grown and available commercially in Thailand, were screened against HIV-1 RT.
The results showed that the water extracts of A.
blazei and I.
obliquus, the ethanol extracts of I.
obliquus and P.
igniarius and the hexane extract of I.
obliquus exhibited strong anti-HIV-1 RT activity with IC50 values of 1.92 ± 0.15, 4.39 ± 0.79, 6.17 ± 0.76 and 7.75 ± 246 mg/ml, respectively.
These mushrooms have the potential for HIV treatment, and further study on identification of the bioactive compounds against HIV-1 RT should be performed.
American Psychological Association (APA)
Choengpanya, Khuanjarat& Ratanabunyong, Siriluk& Seetaha, Supaphorn& Tabtimmai, Lueacha& Choowongkomon, Kiattawee. 2021. Anti-HIV-1 reverse transcriptase property of some edible mushrooms in Asia. Saudi Journal of Biological Sciences،Vol. 28, no. 5, pp.2807-2815.
https://search.emarefa.net/detail/BIM-1414518
Modern Language Association (MLA)
Choengpanya, Khuanjarat…[et al.]. Anti-HIV-1 reverse transcriptase property of some edible mushrooms in Asia. Saudi Journal of Biological Sciences Vol. 28, no. 5 (2021), pp.2807-2815.
https://search.emarefa.net/detail/BIM-1414518
American Medical Association (AMA)
Choengpanya, Khuanjarat& Ratanabunyong, Siriluk& Seetaha, Supaphorn& Tabtimmai, Lueacha& Choowongkomon, Kiattawee. Anti-HIV-1 reverse transcriptase property of some edible mushrooms in Asia. Saudi Journal of Biological Sciences. 2021. Vol. 28, no. 5, pp.2807-2815.
https://search.emarefa.net/detail/BIM-1414518
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 2814-2815
Record ID
BIM-1414518