Formulation and optimization of polyamide disulfide nanoparticles of cromolyn by factorial design
Dissertant
Thesis advisor
University
Isra University
Faculty
Faculty of Pharmacy
University Country
Jordan
Degree
Master
Degree Date
2021
Arabic Abstract
أن الهدف الرئيسي في هذه الدراسة هو استخدام الجسيمات النانوية من مادة البولي أميد – ثاني كبريتيد كنظام لتوصيل الدواء.
استخدمنا الكرومولين لتشكل مركب نانوي درسنا في هذا العمل تأثير المتغير المستقل (كرومولين بوليمر pH FeCl على المتغير التابع، جهد زيتا، حجم الجسيمات) باستخدام برنامج 18 Minitab للتقييم التركيبة التي جهزناها أعطت نظام توصيل دواء أفضل للكرومولين و حسنت امتصاصه و استقراره و توافره الحيوي و ملف تعريف الإطلائق من خلال اعطاء اطالة ممتدة ل 23 ساعة تم ايضا دراسة جميع الصفات الفيزيائية و الكيميائية لهذا المركب عن طريق العديد من الأجهزة و من ضمنها الأشعة تحت الحمراء FTIR و دراسة الطلائق الدواء في المختبر.
English Abstract
The importance of using nanoparticles as drug carriers is due to their high carrier capacity, high stability, probability of incorporation of both lipophilic and lipophobic drugs, and probability of various routes of administration, including inhalation and oral routes.
This study involved the preparation of cromolyn-polyamide-disulfide to nanoparticles overcome the problem of cromolyn frequent dose.
The cromolyn-polyamide-disulfide samples were prepared using various amounts of both cromolyn (0.05, 0.10 and 0.20 g) and polymer (0.05, 0.10 and 0.20 mg) at different pH values (2.2 and 4.4) with different amounts of ferric chloride FeCl3 (0.6, 0.3 and 1.2 g).
The produced nanoparticles were characterized by Fourier Transform Infrared (FTIR) and in vitro release.
FTIR assessments were performed to estimate the functional group(s) of cromolyn-loaded polyamide-disulfide nanoparticles.
Full factorial design (Minitab 18) was used for the purpose of analyzing the results by using graphical analysis such as surface and contour plots, Pareto chart, main effect plots, normal probability plot of the residuals and residuals versus corresponding predicted values plots and interaction plots.
The independent variables were cromolyn, polymer, FeCl3 and pH, while the loading efficiency, zeta potential and particle size were the dependent variables.
Through experiments, we were able to obtain nanoparticles to carry and preserve the drug and provide Prolonged release of cromolyn
Main Subjects
No. of Pages
66
Table of Contents
Table of contents.
Abstract.
Abstract in Arabic.
Chapter One : Introduction.
Chapter Two : Literature review.
Chapter Three : Methodology.
Chapter Four : Results and discussion.
Chapter Five : Conclusion and recommendation for further research.
References.
American Psychological Association (APA)
al-Kurdi, Nadin Muhammad. (2021). Formulation and optimization of polyamide disulfide nanoparticles of cromolyn by factorial design. (Master's theses Theses and Dissertations Master). Isra University, Jordan
https://search.emarefa.net/detail/BIM-1414570
Modern Language Association (MLA)
al-Kurdi, Nadin Muhammad. Formulation and optimization of polyamide disulfide nanoparticles of cromolyn by factorial design. (Master's theses Theses and Dissertations Master). Isra University. (2021).
https://search.emarefa.net/detail/BIM-1414570
American Medical Association (AMA)
al-Kurdi, Nadin Muhammad. (2021). Formulation and optimization of polyamide disulfide nanoparticles of cromolyn by factorial design. (Master's theses Theses and Dissertations Master). Isra University, Jordan
https://search.emarefa.net/detail/BIM-1414570
Language
English
Data Type
Arab Theses
Record ID
BIM-1414570
