Synthesis and characterization of poly (Ester Amide)s based on L-arginine amino acid designed for olfactory drug carrier
Other Title(s)
توليف و توصيف بولي (استر أميدي) مبني على أساس الحمض الأميني إل أرجنين مصممه لحمل الأدوية الشمية
Dissertant
al-Baldawi, Nur Muhammad Nimah
Thesis advisor
University
Isra University
Faculty
Faculty of Pharmacy
University Country
Jordan
Degree
Master
Degree Date
2022
English Abstract
A novel nanocapsules poly(ester-amide) based on the L-arginine amino acid loaded with carbamazepine was synthesized by interfacial polycondensation as a drug carrier for olfactory drugs.
That can take the carbamazepine directly to the brain.
Fourier transform infrared spectroscopy (FTIR) and nuclear magnetic resonance (NMR) characterized poly (ester-amide) to confirm the structure.
Scanning electron microscope (SEM) also done to show the morphology of the formula and zeta sizer confirmed the particle diameter.
X-ray diffraction (XRD) and differential scanning calorimetry (DSC) study proves that carbamazepine dispersed in the nanocapsules did not change its crystallinity.
Quality by design model took place to know the best method used with polymer formation according to three factors, carbamazepine concentration, aqueous phase volume, and organic phase volume.
Then, employing the results obtained from individual and interactive effects on the responses, the best area in which all the results of the responses are within the desired range limits such as low particle size (200-400 nm), high entrapment efficiency (80-100%), high encapsulation efficiency (15-30%) and targeted release (40-80% after 24 hr).
The animal study finding revealed that intranasal treatment with nanocapsules could deliver carbamazepine directly to the brain and obtain a sustained increase in brain concentration at 2, 5, and 10 minutes after the treatment.
Main Subjects
No. of Pages
76
Table of Contents
Table of contents.
Abstract.
Abstract in Arabic.
Chapter One : Introduction.
Chapter Two : Literature review.
Chapter Three : Methodology.
Chapter Four : Results and analyses.
Chapter Five : Conclusions.
References.
American Psychological Association (APA)
al-Baldawi, Nur Muhammad Nimah. (2022). Synthesis and characterization of poly (Ester Amide)s based on L-arginine amino acid designed for olfactory drug carrier. (Master's theses Theses and Dissertations Master). Isra University, Jordan
https://search.emarefa.net/detail/BIM-1414573
Modern Language Association (MLA)
al-Baldawi, Nur Muhammad Nimah. Synthesis and characterization of poly (Ester Amide)s based on L-arginine amino acid designed for olfactory drug carrier. (Master's theses Theses and Dissertations Master). Isra University. (2022).
https://search.emarefa.net/detail/BIM-1414573
American Medical Association (AMA)
al-Baldawi, Nur Muhammad Nimah. (2022). Synthesis and characterization of poly (Ester Amide)s based on L-arginine amino acid designed for olfactory drug carrier. (Master's theses Theses and Dissertations Master). Isra University, Jordan
https://search.emarefa.net/detail/BIM-1414573
Language
English
Data Type
Arab Theses
Record ID
BIM-1414573
