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Lucrative antioxidant effect of metformin against cyclophosphamide induced nephrotoxicity
Joint Authors
Daghash, Samir M.
al-Mari, Khalid Salimin
Mubarak, Ayman Salim
Musa, Ihab M.
Hemeg, Hassan Abd Allah
al-Tuhami, Adil F.
al-Subki, Rua Abd Allah
al-Shammari, Hanan Uqlah
Rizq, Hamdi M.
Source
Saudi Journal of Biological Sciences
Issue
Vol. 28, Issue 5 (31 May. 2021), pp.2755-2761, 7 p.
Publisher
Publication Date
2021-05-31
Country of Publication
Saudi Arabia
No. of Pages
7
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Abstract EN
Cyclophosphamide is anticancer drug with a well-Known nephrotoxicity.
This work was applied to study the lucrative antioxidant influence of metformin as co-therapy on the nephrotoxicity induced by cyclophosphamide in the t reatment of different cancer diseases.
Four groups of male Sprague Dawley rats were used; Control group (C) received single I.P.
injection of 0.2 ml saline, Metformin (MET) group received daily gavage of 200 mg/kg metformin for two weeks, Cyclophosphamide (CP) group received single I.P.
injection of 200 mg/kg CP, Protector group (CP.MET) received daily gavage of 200 mg/kg met-formin for two weeks and single I.P.
injection of 200 mg/kg CP at day 7.
By day 14 rats were euthanized.
Samples were collected from kidney tissues and blood for kidney function evaluation, histopathological and assessment of oxidative stress markers.
The results disclosed that CP yields many functional and structural damage to the kidney, worsened oxidative stress markers and kidney function indicators.
The protector group displayed better kidney tissue morphology, acceptable kidney function indicators as well as satisfactory oxidative stress markers.
In assumption, metformin could be combined with CP owing to its lucrative effect counter to CP per- suaded nephrotoxicity.
American Psychological Association (APA)
al-Tuhami, Adil F.& Musa, Ihab M.& Rizq, Hamdi M.& Daghash, Samir M.& al-Subki, Rua Abd Allah& Mubarak, Ayman Salim…[et al.]. 2021. Lucrative antioxidant effect of metformin against cyclophosphamide induced nephrotoxicity. Saudi Journal of Biological Sciences،Vol. 28, no. 5, pp.2755-2761.
https://search.emarefa.net/detail/BIM-1414617
Modern Language Association (MLA)
al-Tuhami, Adil F.…[et al.]. Lucrative antioxidant effect of metformin against cyclophosphamide induced nephrotoxicity. Saudi Journal of Biological Sciences Vol. 28, no. 5 (2021), pp.2755-2761.
https://search.emarefa.net/detail/BIM-1414617
American Medical Association (AMA)
al-Tuhami, Adil F.& Musa, Ihab M.& Rizq, Hamdi M.& Daghash, Samir M.& al-Subki, Rua Abd Allah& Mubarak, Ayman Salim…[et al.]. Lucrative antioxidant effect of metformin against cyclophosphamide induced nephrotoxicity. Saudi Journal of Biological Sciences. 2021. Vol. 28, no. 5, pp.2755-2761.
https://search.emarefa.net/detail/BIM-1414617
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 2760-2761
Record ID
BIM-1414617