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Lycopene is superior to moringa in improving fertility markers in diet-induced obesity male rats
Joint Authors
Greish, Sahar M.
Abd al-Qadi, Ghadah S.
Abd al-Aziz, Iman Z.
al-Tamani, Dalia A.
Salam, Hana S.
Abu grishah, Nuha M.
Source
Saudi Journal of Biological Sciences
Issue
Vol. 28, Issue 5 (31 May. 2021), pp.2956-2963, 8 p.
Publisher
Publication Date
2021-05-31
Country of Publication
Saudi Arabia
No. of Pages
8
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Abstract EN
Obesity is a condition of chronic tissue inflammation and oxidative stress that poses as a risk factor for male infertility.
Moringa oleifera oil extract is known to have cholesterol-lowering properties and a potential to treat obesity, while lycopene is a potent antioxidant.
We hypothesize that Moringa or lyco- pene may improve male fertility markers in an animal model of diet-induced obesity.
Male Albino rats (n = 60) were randomized to receive regular chow (RC) or high-fat diet (HFD) for 12 weeks (n = 30 each).
Animals in each arm were further randomized to receive gavage treatment with corn oil (vehicle), lyco- pene (10 mg/kg), or Moringa (400 mg/kg) for four weeks starting on week 9 (n = 10 each).
Animals were sacrificed at 12 weeks, and blood was collected to assess lipid profile, serum testosterone, and gonado- tropin levels.
The testes and epididymides were removed for sperm analysis, oxidative stress and inflam- matory markers, and histopathological assessment.
In comparison to their RC littermates, animals on HFD showed an increase in body weights, serum lipids, testosterone and gonadotrophin levels, testicular oxidative stress and inflammatory markers, as well as sperm abnormalities and disrupted testicular his- tology.
Moringa or lycopene reduced body weight, improved oxidative stress, and male fertility markers in HFD-fed animals with lycopene exhibiting better anti-antioxidant and anti-lipidemic effects.
Lycopene is superior to Moringa in improving male fertility parameters, possibly by attenuating oxidative stress.
American Psychological Association (APA)
Greish, Sahar M.& Abd al-Qadi, Ghadah S.& Abd al-Aziz, Iman Z.& al-Tamani, Dalia A.& Salam, Hana S.& Abu grishah, Nuha M.. 2021. Lycopene is superior to moringa in improving fertility markers in diet-induced obesity male rats. Saudi Journal of Biological Sciences،Vol. 28, no. 5, pp.2956-2963.
https://search.emarefa.net/detail/BIM-1415253
Modern Language Association (MLA)
Greish, Sahar M.…[et al.]. Lycopene is superior to moringa in improving fertility markers in diet-induced obesity male rats. Saudi Journal of Biological Sciences Vol. 28, no. 5 (2021), pp.2956-2963.
https://search.emarefa.net/detail/BIM-1415253
American Medical Association (AMA)
Greish, Sahar M.& Abd al-Qadi, Ghadah S.& Abd al-Aziz, Iman Z.& al-Tamani, Dalia A.& Salam, Hana S.& Abu grishah, Nuha M.. Lycopene is superior to moringa in improving fertility markers in diet-induced obesity male rats. Saudi Journal of Biological Sciences. 2021. Vol. 28, no. 5, pp.2956-2963.
https://search.emarefa.net/detail/BIM-1415253
Data Type
Journal Articles
Language
English
Notes
Record ID
BIM-1415253