Comparison of Apolipoprotein B, NON-HDL-C, AND LDL-C : towards more accurate predictor test for ischemic heart diseases in a sample of Syrian males

Abstract EN

Objective: Low-density lipoprotein cholesterol (LDL-C) only partly represents the atherogenic lipid burden, and a growing body of evidence suggests that none high-density lipoprotein cholesterol (Non-HDL-C), and Apolipoprotein B (ApoB) are more accurate in estimating lipid-related Atherosclerotic cardiovascular disease such as ischemic heart disease (IHD).

The aim of this study was to compare Apo B, Non-HDL-C, and LDL-C to identify the most accurate and predictive test for IHD.

Methods: A case-control study, 200 males; 100 patients suffer from ischemic heart disease were taken from the Cardiology Department of Al-Mouwasat University Hospital in Damascus, and 100 healthy persons, Participants' data were taken(age, education, anthropometric measurements, smoking and alcohol consumption, diabetes and hypertension), then laboratory tests were done (creatinine, albumin, glucose, cholesterol, triacylglycerol, HDL-C, ApoB, CRP) and the values of LDL-C and Non-HDL-C were calculated.

The results were compared using T test and the SPSS program, the correlation, accuracy, prediction were studied.

Results: ApoB test was the most significant and strongest predictor for IHD, followed by Non-HDL-C, but LDL-C had not acceptable predictive value.

Conclusions: This study recommends perform of ApoB as the best test to predict IHD if it is available, calculate Non-HDL-C in all cases routinely, LDL-C was not reliable.