تظاهر ارتشاح جلدي بلمفوما الخلايا اللمفاوية الصغيرة ككتلة معزولة في الثدي : تقرير حالة طبية و مراجعة في الأدب الطبي

Abstract EN

Skin infiltration with b-lymphocytes is considered a form of leukaemia cutis, it is seen in 4-20% of chronic lymphocytic leukemias/small lymphocytes lymphomas CLL/SLL.

about 2% to 3% of leukaemia cutis happen before myeloid infiltration or peripheral blood stream and in the absence of systemic symptoms.

this uncommon condition is known as “aleukaemic leukaemia cutis” or “primary extramedullary leukemia”.

the infiltration within breast skin primarily without systemic or nodular involvement is very rare.

in this paper we report a case of a 46-yearold married woman who has a violaceous macular lesion on the skin of the right breast; that developed later to a nodule with stinging pain, no other associated symptoms.

radiological studies and breast ultra sound showed normal findings.

the skin biopsy and immunological stains showed infiltration with (CD20 positive) lymphocytes consistent with CLL/SLL.

Hematological studies showed no increase in lymphocytes count, bone marrow biopsy didn’t show any abnormalities.

the case was diagnosed as SLL in breast skin stage IV (according to ann-arbor staging system).

the patient was treated with chemotherapy, and now and after five years continues to be in good health without any abnormalities.