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تعيين مستويات بروستاغلاندين د 2 سيننثاز في السائل الدماغي الشوكي لدى أطفال مصابين أورام دماغية
Other Title(s)
Determination of prostaglandin d2 synthase levels in cerebrospinal fluid in children with brain tumors
Joint Authors
Source
المجلة العربية للعلوم الصيدلية
Issue
Vol. 6, Issue 3 (31 May. 2020), pp.47-53, 7 p.
Publisher
Publication Date
2020-05-31
Country of Publication
Syria
No. of Pages
7
Main Subjects
Pharmacy, Health & Medical Sciences
Medicine
Abstract EN
Prostaglandin d2 synthase pgd2s, also known as β-trace, is one of the most abundant glycoproteins in human CSF; it is synthesized and secreted by both glial cells and the choroid plexus.
it synthesizes of prostaglandin pgd2 from pgh2, and plays an important role in context of pathways related to cellular proliferation, cell cycle regulation, anti-inflammatory role and innate immune functions.
that is expected to be modulated during cancer progression, and it has extracellular protease inhibitory properties, which restrict tumor growth in tissue.
to evaluate prostaglandin d2 synthase levels in CSF in children as a diagnostic marker for brain tumors, we determined pgd2s levels in a group of children with brain tumors (cases n=30) and in a group of healthy children (control, n=22).
pgd2s levels were lower in group of patients (52.83 μg/ml) than control (61.51 μg/ml), (p< 0.05), and according to the roc curve (AUC= 0.72, p< 0.05) the cut off was 53.55 μg /ml (PPV= 0.60, NPV= 1.00).
there was a statistically significant inverse correlation between pgd2s levels and tumor grade.
our results suggest diagnostic significant of pgd2s levels as a general biomarker for pediatric brain tumors.
American Psychological Association (APA)
عارف مراد وزيتون، المعتصم بالله. 2020. تعيين مستويات بروستاغلاندين د 2 سيننثاز في السائل الدماغي الشوكي لدى أطفال مصابين أورام دماغية. المجلة العربية للعلوم الصيدلية،مج. 6، ع. 3، ص ص. 47-53.
https://search.emarefa.net/detail/BIM-1424274
Modern Language Association (MLA)
عارف مراد وزيتون، المعتصم بالله. تعيين مستويات بروستاغلاندين د 2 سيننثاز في السائل الدماغي الشوكي لدى أطفال مصابين أورام دماغية. المجلة العربية للعلوم الصيدلية مج. 6، ع. 3 (أيار 2020)، ص ص. 47-53.
https://search.emarefa.net/detail/BIM-1424274
American Medical Association (AMA)
عارف مراد وزيتون، المعتصم بالله. تعيين مستويات بروستاغلاندين د 2 سيننثاز في السائل الدماغي الشوكي لدى أطفال مصابين أورام دماغية. المجلة العربية للعلوم الصيدلية. 2020. مج. 6، ع. 3، ص ص. 47-53.
https://search.emarefa.net/detail/BIM-1424274
Data Type
Journal Articles
Language
Arabic
Notes
يتضمن مراجع ببليوجرافية : ص. 52-53
Record ID
BIM-1424274