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ترابط التعدد الشكلي rs79O3146 لجين TCF7L2 مع السكري من النمط الثاني لدى سكان من سورية
Other Title(s)
Association of TCF7L2rs7903146gene polymorphism with type 2 diabetes mellitus in Syrian population
Joint Authors
القبيلي، فايزة
مخزوم، أسامة
قبلان، يونس محمد
Source
المجلة العربية للعلوم الصيدلية
Issue
Vol. 6, Issue 1 (31 Jul. 2019), pp.8-15, 8 p.
Publisher
Publication Date
2019-07-31
Country of Publication
Syria
No. of Pages
8
Main Subjects
Abstract EN
Background: Type 2 diabetes is thought to be a polygenic disorder that develops as a result of a complex interaction between multiple genes and environmental factors.
TCF7L2 is one of the most important genes have been associated with T2DM in the Genome-wide association studies.
This research aimed to study the association of rs7903146polymorphism of the gene TCF7L2 with T2DM in a sample of Syrian population.
Methods: This case control studyinvolved 138 individuals: the control group (63 individuals) and the T2DM group (75 individuals).
The TCF7L2 rs7903146polymorphism was genotyped by Restriction Fragment Length Polymorphism (RFLP).
Results: The frequency of the risk allele Tin the T2DM and healthygroups (38.7% vs 30.2%) respectively, and the difference was statistically insignificant (P = 0.139).
The frequency of the TT genotype was significantly higher in the T2DM group, compared to the healthy group (16% vs.
3.2%), and it wassignificantly associated with T2DM, with an OR of 5.586 (95% CI 0.144 - 27.286, P = 0.021).
However, the frequency of CT genotype in the two groups were (45.3% vs.
54%), and the difference was statistically insignificant (P = 0.843).
Conclusions: This research showed that rs7903146polymorphism of the TCF7L2 gene is an important risk factor for type 2 diabetes mellitus in a sample of Syrian population.
American Psychological Association (APA)
مخزوم، أسامة وقبلان، يونس محمد والقبيلي، فايزة. 2019. ترابط التعدد الشكلي rs79O3146 لجين TCF7L2 مع السكري من النمط الثاني لدى سكان من سورية. المجلة العربية للعلوم الصيدلية،مج. 6، ع. 1، ص ص. 8-15.
https://search.emarefa.net/detail/BIM-1424437
Modern Language Association (MLA)
مخزوم، أسامة....[و آخرون]. ترابط التعدد الشكلي rs79O3146 لجين TCF7L2 مع السكري من النمط الثاني لدى سكان من سورية. المجلة العربية للعلوم الصيدلية مج. 6، ع. 1 (تموز 2019)، ص ص. 8-15.
https://search.emarefa.net/detail/BIM-1424437
American Medical Association (AMA)
مخزوم، أسامة وقبلان، يونس محمد والقبيلي، فايزة. ترابط التعدد الشكلي rs79O3146 لجين TCF7L2 مع السكري من النمط الثاني لدى سكان من سورية. المجلة العربية للعلوم الصيدلية. 2019. مج. 6، ع. 1، ص ص. 8-15.
https://search.emarefa.net/detail/BIM-1424437
Data Type
Journal Articles
Language
Arabic
Notes
يتضمن مراجع ببليوجرافية : ص. 14-15
Record ID
BIM-1424437