تقييم تأثير معززات نفاذية جلدية على تحرر و نفاذية التستوستيرون من هلامات مائية
Other Title(s)
Evaluation of the effect of some dermal penetration enhancers on the release and permeation of testosterone from Hydrogels
Joint Authors
Source
المجلة العربية للعلوم الصيدلية
Issue
Vol. 5, Issue 8 (31 Mar. 2018), pp.19-30, 12 p.
Publisher
Publication Date
2018-03-31
Country of Publication
Syria
No. of Pages
12
Main Subjects
Pharmacy, Health & Medical Sciences
Abstract EN
The aim of this study is to choose a suitable dermal penetration enhancer for testosterone in hydrogels.
Seven formulations of testosterone hydrogels containing one penetration enhancer (Propylene glycol, Limonene, Oleic acid or Transcutol) or combination of two enhancers, one of them is Propylene glycol and the other one is Transcutol, Limonene or Oleic acid were prepared.
The formulations were evaluated by Testosterone release from Polyvinylidene fluoride membranes (PVDF) 0.22 μ, moreover the penetration through rat ́s skin (in vitro) was evaluated using Vankel enhancer cell.
The amount of testosterone permeated from hydrogel F5 (which contain limonene and propylene glycol as penetration enhancers) through rat skin (in vitro) in 24 hours was more than the amount permeated from Androgel % with statistically significant difference at confidence level α=0.05.
The results also showed a synergic action between propylene glycol and limonene in enhancing the permeation of testosterone through rat ́s skin.
It showed that using of propylene glycol (in concentration of 15%) in testosterone hydrogels leads to increase the release of testosterone from these hydrogels
American Psychological Association (APA)
علي بلال والزين، هند الفاتح. 2018. تقييم تأثير معززات نفاذية جلدية على تحرر و نفاذية التستوستيرون من هلامات مائية. المجلة العربية للعلوم الصيدلية،مج. 5، ع. 8، ص ص. 19-30.
https://search.emarefa.net/detail/BIM-1424910
Modern Language Association (MLA)
علي بلال والزين، هند الفاتح. تقييم تأثير معززات نفاذية جلدية على تحرر و نفاذية التستوستيرون من هلامات مائية. المجلة العربية للعلوم الصيدلية مج. 5، ع. 8 (آذار 2018)، ص ص. 19-30.
https://search.emarefa.net/detail/BIM-1424910
American Medical Association (AMA)
علي بلال والزين، هند الفاتح. تقييم تأثير معززات نفاذية جلدية على تحرر و نفاذية التستوستيرون من هلامات مائية. المجلة العربية للعلوم الصيدلية. 2018. مج. 5، ع. 8، ص ص. 19-30.
https://search.emarefa.net/detail/BIM-1424910
Data Type
Journal Articles
Language
Arabic
Notes
يتضمن مراجع ببليوجرافية : ص. 28-30
Record ID
BIM-1424910