تقييم تأثير الميثيل سلفونيل ميثان في علاج القرحة المعدية المحدثة بالبيسفسونات لدى الجرذان
Other Title(s)
Evaluation of therapeutic effect of methyl sulfonyl methane on peptic ulcer induced by bisphosphonates in rats
Joint Authors
مدور، صفاء وليم
منديلي، أحمد عزت
اللحام، شذى أنور
Source
المجلة العربية للعلوم الصيدلية
Issue
Vol. 5, Issue 8 (31 Mar. 2018), pp.41-50, 10 p.
Publisher
Publication Date
2018-03-31
Country of Publication
Syria
No. of Pages
10
Main Subjects
Pharmacy, Health & Medical Sciences
Abstract EN
Gastric ulceration is a common adverse effect of many medication, including Non- steroidal anti-inflammatory drugs (NSAIDs) and bisphosphonates (BPs) that is used for osteoporosis.
Bisphosphonates use is associated with peptic ulcer manifested, in its severe state, in hemorrhage and perforation.
Methyl sulfonyl methane (MSM) was used in different doses to cure BPs ulceration.
Our research aimed to study the effect of MSM in treatment of peptic ulcer induced by Alendronate in rats.
The experiments had been done on 8 white wistar rats for each studied group.
The gastric ulcer has been induced by oral administration of Alendronate (20mg/kg/day) for 4 days.
400 mg/kg/day of MSM has been given for the first therapeutic group for 4 days, after administration of Alendronate.
While the other therapeutic group has been given 800 mg/kg/day of MSM.
The gastric ulcers in rats' stomachs were examined histologically and microscopically.
The ulcer index and curative index were measured, and the statistical analyses were carried out.
Results showed the efficacy of MSM in treatment of peptic ulcer induced by alendronate, that administration of MSM, in both doses, after inducing ulcer led to reduction in ulcer index and gave significant difference comparing with morbidity group.
American Psychological Association (APA)
مدور، صفاء وليم ومنديلي، أحمد عزت واللحام، شذى أنور. 2018. تقييم تأثير الميثيل سلفونيل ميثان في علاج القرحة المعدية المحدثة بالبيسفسونات لدى الجرذان. المجلة العربية للعلوم الصيدلية،مج. 5، ع. 8، ص ص. 41-50.
https://search.emarefa.net/detail/BIM-1424915
Modern Language Association (MLA)
مدور، صفاء وليم....[و آخرون]. تقييم تأثير الميثيل سلفونيل ميثان في علاج القرحة المعدية المحدثة بالبيسفسونات لدى الجرذان. المجلة العربية للعلوم الصيدلية مج. 5، ع. 8 (آذار 2018)، ص ص. 41-50.
https://search.emarefa.net/detail/BIM-1424915
American Medical Association (AMA)
مدور، صفاء وليم ومنديلي، أحمد عزت واللحام، شذى أنور. تقييم تأثير الميثيل سلفونيل ميثان في علاج القرحة المعدية المحدثة بالبيسفسونات لدى الجرذان. المجلة العربية للعلوم الصيدلية. 2018. مج. 5، ع. 8، ص ص. 41-50.
https://search.emarefa.net/detail/BIM-1424915
Data Type
Journal Articles
Language
Arabic
Notes
يتضمن مراجع ببليوجرافية : ص. 49-50
Record ID
BIM-1424915